Evidence map›Paper›PMID 27511985›Full record

ArticlePhysiological reports2016

The response of muscle protein synthesis following whole-body resistance exercise is greater following 40 g than 20 g of ingested whey protein.

Lindsay S Macnaughton, Sophie L Wardle, Oliver C Witard, Chris McGlory, D Lee Hamilton, Stewart Jeromson, Clare E Lawrence, Gareth A Wallis, Kevin D Tipton

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Article in Physiological reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lindsay S MacnaughtonHealth and Exercise Sciences Research Group, University of Stirling, Stirling, Scotland.
Sophie L WardleHealth and Exercise Sciences Research Group, University of Stirling, Stirling, Scotland.
Oliver C WitardHealth and Exercise Sciences Research Group, University of Stirling, Stirling, Scotland.
Chris McGloryExercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
D Lee HamiltonHealth and Exercise Sciences Research Group, University of Stirling, Stirling, Scotland.
Stewart JeromsonHealth and Exercise Sciences Research Group, University of Stirling, Stirling, Scotland.
Clare E LawrenceGlaxoSmithKline Consumer Healthcare, Brentford, UK.
Gareth A WallisSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
Kevin D TiptonHealth and Exercise Sciences Research Group, University of Stirling, Stirling, Scotland k.d.tipton@stir.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The currently accepted amount of protein required to achieve maximal stimulation of myofibrillar protein synthesis (MPS) following resistance exercise is 20-25 g. However, the influence of lean body mass (LBM) on the response of MPS to protein ingestion is unclear. Our aim was to assess the influence of LBM, both total and the amount activated during exercise, on the maximal response of MPS to ingestion of 20 or 40 g of whey protein following a bout of whole-body resistance exercise. Resistance-trained males were assigned to a group with lower LBM (≤65 kg; LLBM n = 15) or higher LBM (≥70 kg; HLBM n = 15) and participated in two trials in random order. MPS was measured with the infusion of (13)C6-phenylalanine tracer and collection of muscle biopsies following ingestion of either 20 or 40 g protein during recovery from a single bout of whole-body resistance exercise. A similar response of MPS during exercise recovery was observed between LBM groups following protein ingestion (20 g - LLBM: 0.048 ± 0.018%·h(-1); HLBM: 0.051 ± 0.014%·h(-1); 40 g - LLBM: 0.059 ± 0.021%·h(-1); HLBM: 0.059 ± 0.012%·h(-1)). Overall (groups combined), MPS was stimulated to a greater extent following ingestion of 40 g (0.059 ± 0.020%·h(-1)) compared with 20 g (0.049 ± 0.020%·h(-1); P = 0.005) of protein. Our data indicate that ingestion of 40 g whey protein following whole-body resistance exercise stimulates a greater MPS response than 20 g in young resistance-trained men. However, with the current doses, the total amount of LBM does not seem to influence the response.

Indexed as

AdultAmino AcidsBody Weights and MeasuresExerciseHumansMaleMuscle ProteinsMuscle, SkeletalMyofibrilsPhenylalanineUreaWhey ProteinsYoung AdultAmino AcidsMuscle ProteinsPhenylalanineUreaWhey ProteinsFractional synthesis rateintracellular signaling proteinslean body massprotein dose‐response

Identifiers

PMID27511985
PMCPMC4985555

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.