ArticlePhysiological reports2016
Mitochondrial function assessed by 31P MRS and BOLD MRI in non-obese type 2 diabetic rats.
Article in Physiological reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Altered acute metabolic response to muscle stimulation in muscular dystrophic mice observed by phosphorus-31 magnetic resonance spectroscopy and fingerprinting.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Imaging of Sarcopenia in Type 2 Diabetes Mellitus.Clinical interventions in aging · 2024Review
- High-Resolution DynamicIEEE transactions on bio-medical engineering · 2020Article
- Mitochondrial Utilization of Competing Fuels Is Altered in Insulin Resistant Skeletal Muscle of Non-obese Rats (Goto-Kakizaki).Frontiers in physiology · 2020Article
- Quantification of Mitochondrial Oxidative Phosphorylation in Metabolic Disease: Application to Type 2 Diabetes.International journal of molecular sciences · 2019Review
- Skeletal muscle energetics are compromised only during high-intensity contractions in the Goto-Kakizaki rat model of type 2 diabetes.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- High-resolution MRI of kidney microstructures at 7.05 T with an endo-colonic Wireless Amplified NMR detector.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2019Article
- Assessing tissue metabolism by phosphorous-31 magnetic resonance spectroscopy and imaging: a methodology review.Quantitative imaging in medicine and surgery · 2017Review
- Article
- High-resolution dynamicMagnetic resonance in medicine · 2017Article
- Defects in skeletal muscle subsarcolemmal mitochondria in a non-obese model of type 2 diabetes mellitus.PloS one · 2017Article
- Mitochondrial function assessed by 31P MRS and BOLD MRI in non-obese type 2 diabetic rats.Physiological reports · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The study aims to characterize age-associated changes in skeletal muscle bioenergetics by evaluating the response to ischemia-reperfusion in the skeletal muscle of the Goto-Kakizaki (GK) rats, a rat model of non-obese type 2 diabetes (T2D). (31)P magnetic resonance spectroscopy (MRS) and blood oxygen level-dependent (BOLD) MRI was performed on the hindlimb of young (12 weeks) and adult (20 weeks) GK and Wistar (control) rats. (31)P-MRS and BOLD-MRI data were acquired continuously during an ischemia and reperfusion protocol to quantify changes in phosphate metabolites and muscle oxygenation. The time constant of phosphocreatine recovery, an index of mitochondrial oxidative capacity, was not statistically different between GK rats (60.8 ± 13.9 sec in young group, 83.7 ± 13.0 sec in adult group) and their age-matched controls (62.4 ± 11.6 sec in young group, 77.5 ± 7.1 sec in adult group). During ischemia, baseline-normalized BOLD-MRI signal was significantly lower in GK rats than in their age-matched controls. These results suggest that insulin resistance leads to alterations in tissue metabolism without impaired mitochondrial oxidative capacity in GK rats.
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