ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2016
Ticagrelor regulates osteoblast and osteoclast function and promotes bone formation in vivo via an adenosine-dependent mechanism.
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In one paragraph
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
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Who cites it
47 citing papers in PubMed, 67 citations in OpenAlex.
- Extracellular Adenosine Contributes to the Hydrogen Peroxide-Induced Calcification of Cultured Tendon Cells.Current issues in molecular biology · 2026Article
- Safety profile of ticagrelor: an analysis based on literature and database review.BMC cardiovascular disorders · 2026Review
- Cranial Defect Reconstruction With Custom 3D-Printed Hydroxyapatite Scaffolds Augmented With rhBMP-2 or Dipyridamole in a Nonhuman Primate Model.Journal of tissue engineering and regenerative medicine · 2026Article
- Biomimetic Nanoparticles for Bone Regeneration: Construction Strategies and Therapeutic Mechanisms.International journal of nanomedicine · 2026Review
- Crosstalk between ferroptosis and NLRP3, a possible therapeutic target in experimentally-induced rheumatoid arthritis: role of P2Y12R inhibition in modulating P53/SLC7A11/ALOX15 signaling.Inflammopharmacology · 2025Article
- 3D-printing of dipyridamole/thermoplastic polyurethane materials for bone regeneration.Drug delivery and translational research · 2025Article
- Adenosine metabolism and receptors in aging of the skin, musculoskeletal, immune and cardiovascular systems.Ageing research reviews · 2025Review
- Clopidogrel protects against gentamicin-induced nephrotoxicity through targeting oxidative stress, apoptosis, and coagulation pathways.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- 3D nanocomposites of β-TCP-HScientific reports · 2025Article
- Effect of antiplatelet and anticoagulant medications on implant survival: a long-term retrospective cohort study.Oral and maxillofacial surgery · 2025Article
- Impact of Medications for Stable Angina Pectoris on Osteoporosis: A Review of Current Evidence.Journal of multidisciplinary healthcare · 2025Review
- Biomimetic Tissue Engineering Strategies for Craniofacial Applications.Biomimetics (Basel, Switzerland) · 2024Review
- Translational Experimental Basis of Indirect Adenosine Receptor Agonist Stimulation for Bone Regeneration: A Review.International journal of molecular sciences · 2024Review
- Amino acid-based supramolecular chiral hydrogels promote osteogenesis of human dental pulp stem cells via the MAPK pathway.Materials today. Bio · 2024Article
- Ticagrelor was associated with lower fracture risk than clopidogrel in the dual anti-platelet regimen among patients with acute coronary syndrome treated with percutaneous coronary intervention.Journal of endocrinological investigation · 2024Article
- Three-Dimensional Printing Methods for Bioceramic-Based Scaffold Fabrication for Craniomaxillofacial Bone Tissue Engineering.Journal of functional biomaterials · 2024Review
- The Effect of Clopidogrel and Ticagrelor on Human Adipose Mesenchymal Stem Cell Osteogenic Differentiation Potential:Advances in pharmacological and pharmaceutical sciences · 2024Article
- Bone Tissue Engineering (BTE) of the Craniofacial Skeleton, Part I: Evolution and Optimization of 3D-Printed Scaffolds for Repair of Defects.The Journal of craniofacial surgery · 2023Article
- A Machine Learning-Based Image Segmentation Method to Quantify In Vitro Osteoclast Culture Endpoints.Calcified tissue international · 2023Article
- Extracellular adenosine signaling in bone health and disease.Current opinion in pharmacology · 2023Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Aránzazu MedieroBone and Joint Research Unit, Instituto de Investigación Sanitaria, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain.
Tuere WilderDivision of Translational Medicine, Department of Medicine, New York University (NYU)-Langone Medical Center, New York, New York, USA.
Vishnu S R ReddyDepartment of Biomaterials and Biomimetics, NYU College of Dentistry, New York, New York, USA; and.
Qian ChengDivision of Translational Medicine, Department of Medicine, New York University (NYU)-Langone Medical Center, New York, New York, USA.
Nick TovarDepartment of Biomaterials and Biomimetics, NYU College of Dentistry, New York, New York, USA; and.
Paulo G CoelhoDepartment of Biomaterials and Biomimetics, NYU College of Dentistry, New York, New York, USA; and.
Lukasz WitekDepartment of Biomaterials and Biomimetics, NYU College of Dentistry, New York, New York, USA; and.
Carl WhatlingAstraZeneca R&D Mölndal, Cardiovascular and Metabolic Diseases Innovative Medicine Unit, Translational Sciences, Mölndal, Sweden.
Bruce N CronsteinDivision of Translational Medicine, Department of Medicine, New York University (NYU)-Langone Medical Center, New York, New York, USA.
BioMimetic Systems (United States) · USNYU Langone Health · USAstraZeneca (Sweden) · SEHospital Universitario Fundación Jiménez Díaz · ESNew York University · US
Funding
Project-005UL1TR001445 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BREDELLA, MIRIAM ANTOINETTE, HOCHMAN, JUDITH S · 2015 to 2025
$103.5MInstitutional Clinical and Translational Science AwardUL1TR000038 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CRONSTEIN, BRUCE NEIL, HOCHMAN, JUDITH S · 2012 to 2014
$16.8MTRABECULAR BONE ADAPTATION TO MECHANICAL LOADINGP30AR046121 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI MYERS, ELIZABETH R. · 1999 to 2010
$5.5MThe Pharmacology of Dermal Fibrosis R01AR056672 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CRONSTEIN, BRUCE NEIL · 2009 to 2018
$4.6MPurinergic Stimulation of Bone RegenerationR01AR068593 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COELHO, PAULO G, CRONSTEIN, BRUCE NEIL · 2015 to 2019
$2.8MPurinergic Regulation of Bone MetabolismR01AR054897 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CRONSTEIN, BRUCE NEIL · 2008 to 2014
$2.1MImmunomodulatory functions of neuronal guidance cuesRC1HL100815 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MOORE, KATHRYN J · 2009 to 2010
$997kThe Pharmacology of Dermal FibrosisR56AR056672 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CRONSTEIN, BRUCE NEIL · 2014 to 2014
$373kNCATS NIH HHS UL1 TR000038NCATS NIH HHS UL1 TR001445NHLBI NIH HHS RC1 HL100815NIAMS NIH HHS P30 AR046121NIAMS NIH HHS R01 AR054897NIAMS NIH HHS R01 AR056672NIAMS NIH HHS R01 AR068593NIAMS NIH HHS R56 AR056672
Abstract
As many as 10% of bone fractures heal poorly, and large bone defects resulting from trauma, tumor, or infection may not heal without surgical intervention. Activation of adenosine A
Indexed as
AdenosineAnimalsBlood PlateletsBone RegenerationClopidogrelDipyridamoleMice, Inbred C57BLOsteoblastsOsteoclastsOsteogenesisPlatelet ActivationReceptor, Adenosine A2ATicagrelorTiclopidineAdenosineClopidogrelDipyridamoleReceptor, Adenosine A2ATicagrelorTiclopidine3-D HA/β-TCP scaffoldsA2ARantiplatelet drugsbone regeneration
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What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.