Evidence map›Paper›PMID 27511907›Full record

ArticleASN neuro2016

Repairing the Brain by SCF+G-CSF Treatment at 6 Months Postexperimental Stroke: Mechanistic Determination of the Causal Link Between Neurovascular Regeneration and Motor Functional Recovery.

Lili Cui, Dandan Wang, Sandra McGillis, Michele Kyle, Li-Ru Zhao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ASN neuro, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Pharmacological Enhancement of Stroke Recovery.Current neurology and neuroscience reports · 2019
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Lili CuiDepartment of Neurosurgery, State University of New York Upstate Medical University, Syracuse, NY, USA Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Dandan WangDepartment of Neurosurgery, State University of New York Upstate Medical University, Syracuse, NY, USA.
Sandra McGillisDepartment of Neurosurgery, State University of New York Upstate Medical University, Syracuse, NY, USA.
Michele KyleDepartment of Neurosurgery, State University of New York Upstate Medical University, Syracuse, NY, USA.
Li-Ru ZhaoDepartment of Neurosurgery, State University of New York Upstate Medical University, Syracuse, NY, USA Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA, USA ZHAOL@upstate.edu.
SUNY Upstate Medical University · USLouisiana State University Health Sciences Center Shreveport · US

Funding

Hematopoietic Growth Factors and Chronic StrokeR01NS060911 · NINDS · UPSTATE MEDICAL UNIVERSITY · PI ZHAO, LI-RU · 2010 to 2014
$1.6M
NINDS NIH HHS R01 NS060911
6 · The paper itself

Abstract

Stroke, a leading cause of adult disability in the world, is a severe medical condition with limited treatment. Physical therapy, the only treatment available for stroke rehabilitation, appears to be effective within 6 months post-stroke. Here, we have mechanistically determined the efficacy of combined two hematopoietic growth factors, stem cell factor (SCF) and granulocyte-colony stimulating factor (G-CSF; SCF + G-CSF), in brain repair 6 months after cortical infarct induction in the transgenic mice carrying yellow fluorescent protein in Layer V pyramidal neurons (Thy1-YFP-H). Using a combination of live brain imaging, whole brain imaging, molecular manipulation, synaptic and vascular assessments, and motor function examination, we found that SCF + G-CSF promoted mushroom spine formation, enlarged postsynaptic membrane size, and increased postsynaptic density-95 accumulation and blood vessel density in the peri-infarct cavity cortex; and that SCF + G-CSF treatment improved motor functional recovery. The SCF + G-CSF-enhanced motor functional recovery was dependent on the synaptic and vascular regeneration in the peri-infarct cavity cortex. These data suggest that a stroke-damaged brain is repairable by SCF + G-CSF even 6 months after the lesion occurs. This study provides novel insights into the development of new restorative strategies for stroke recovery.

Indexed as

AnimalsBrainDendritic SpinesDisease Models, AnimalDisks Large Homolog 4 ProteinEnzyme InhibitorsFunctional LateralityGene Expression RegulationGranulocyte Colony-Stimulating FactorInfarction, Middle Cerebral ArteryIntracellular Signaling Peptides and ProteinsMaleMembrane ProteinsMiceMice, TransgenicMotor Activity3-(4-methylphenylsulfonyl)-2-propenenitrileDisks Large Homolog 4 ProteinDlg4 protein, ratEnzyme InhibitorsGranulocyte Colony-Stimulating FactorIntracellular Signaling Peptides and ProteinsMembrane ProteinsNitrilesPhosphopyruvate HydratasePlatelet Endothelial Cell Adhesion Molecule-1SulfonesTranscription Factor RelAbrain repairchronic strokeG-CSFhematopoietic growth factorslive brain imagingSCF

Identifiers

PMID27511907
PMCPMC4984318
OpenAlexW2477673880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.