Trial reportScientific reports2016
Value of corneal epithelial and Bowman's layer vertical thickness profiles generated by UHR-OCT for sub-clinical keratoconus diagnosis.
Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Bowman's layer and corneal thickness in health and disease.BMJ open ophthalmology · 2025Article
- Corneal Layer Segmentation in Healthy and Pathological Eyes: A Joint Super-Resolution Generative Adversarial Network and Adaptive Graph Theory Approach.Translational vision science & technology · 2025Article
- Corneal Epithelial Thickness Maps in Eyes with Mild and Moderate Keratoconus.Journal of clinical medicine · 2025Article
- Comparison of the repeatability and reproducibility of corneal thickness mapping using optical coherence tomography according to tear film break-up time.BMC ophthalmology · 2024Article
- Multi-modal imaging for the detection of early keratoconus: a narrative review.Eye and vision (London, England) · 2024Review
- Corneal Epithelial Thickness Mapping: A Major Review.Journal of ophthalmology · 2024Review
- Parameters of a basic ophthalmic examination that can ensure proper timing of corneal crosslinking in patients with keratoconus.International ophthalmology · 2023Review
- Accurate In Vivo Bowman's Thickness Measurement Using Mirau Ultrahigh Axial Resolution Line Field Optical Coherence Tomography.Translational vision science & technology · 2022Article
- [Early diagnosis of keratoconus].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2022Article
- Relationship between corneal biomechanical parameters and corneal sublayer thickness measured by Corvis ST and UHR-OCT in keratoconus and normal eyes.Eye and vision (London, England) · 2021Article
- Advances in Imaging Technology of Anterior Segment of the Eye.Journal of ophthalmology · 2021Review
- Dissecting the Profile of Corneal Thickness With Keratoconus Progression Based on Anterior Segment Optical Coherence Tomography.Frontiers in neuroscience · 2021Article
- In-vivo Three-dimensional Characteristics of Bowman's Layer and Endothelium/Descemet's Complex Using Corneal Microlayer Tomography in Healthy Subjects.Current eye research · 2020Article
- Machine learning helps improve diagnostic ability of subclinical keratoconus using Scheimpflug and OCT imaging modalities.Eye and vision (London, England) · 2020Article
- En Face and Cross-sectional Corneal Tomograms Using Sub-micron spatial resolution Optical Coherence Tomography.Scientific reports · 2018Article
- The relationship between corneal biomechanics and anterior segment parameters in the early stage of orthokeratology: A pilot study.Medicine · 2017Observational
- Impact of contact lens wear on epithelial alterations in keratoconus.Journal of optometryArticle
- A review of corneal imaging methods for the early diagnosis of pre-clinical Keratoconus.Journal of optometryReview
- Assessments of tear meniscus height, tear film thickness, and corneal epithelial thickness after deep anterior lamellar keratoplasty.Journal of Zhejiang University. Science. BArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ultra-high resolution optical coherence tomography (UHR-OCT) can image the corneal epithelium and Bowman's layer and measurement the thicknesses. The purpose of this study was to validate the diagnostic power of vertical thickness profiles of the corneal epithelium and Bowman's layer imaged by UHR-OCT in the diagnosis of sub-clinical keratoconus (KC). Each eye of 37 KC patients, asymptomatic fellow eyes of 32 KC patients, and each eye of 81 normal subjects were enrolled. Vertical thickness profiles of the corneal epithelium and Bowman's layer were measured by UHR-OCT. Diagnostic indices were calculated from vertical thickness profiles of each layer and output values of discriminant functions based on individual indices. Receiver operating characteristic curves were determined, and the accuracy of the diagnostic indices were assessed as the area under the curves (AUC). Among all of the individual indices, the maximum ectasia index for epithelium had the highest ability to discriminate sub-clinical KC from normal corneas (AUC = 0.939). The discriminant function containing maximum ectasia indices of epithelium and Bowman's layer further increased the AUC value (AUC = 0.970) for sub-clinical KC diagnosis. UHR-OCT-derived thickness indices from the entire vertical thickness profiles of the corneal epithelium and Bowman's layer can provide valuable diagnostic references to detect sub-clinical KC.
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