Evidence map›Paper›PMID 27511435›Full record

ArticleScientific reports2016

Supersonic shearwave elastography in the assessment of liver fibrosis for postoperative patients with biliary atresia.

Shuling Chen, Bing Liao, Zhihai Zhong, Yanling Zheng, Baoxian Liu, Quanyuan Shan, Xiaoyan Xie, Luyao Zhou

Open access · goldAbstract readComparative StudyEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 3 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.

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  12. Progress in Biomarkers Related to Biliary Atresia.Journal of clinical and translational hepatology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Shuling ChenDepartment of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound , The First Affiliated Hospital of Sun Yat-sen University, No.58 Zhongshan Road 2, Guangzhou, 510080, P.R. China.
Bing LiaoDepartment of pathology , The First Affiliated Hospital of Sun Yat-sen University, No.58 Zhongshan Road 2, Guangzhou, 510080, P.R. China.
Zhihai ZhongDepartment of pediatric surgery, The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou 510080, P. R. China.
Yanling ZhengDepartment of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound , The First Affiliated Hospital of Sun Yat-sen University, No.58 Zhongshan Road 2, Guangzhou, 510080, P.R. China.
Baoxian LiuDepartment of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound , The First Affiliated Hospital of Sun Yat-sen University, No.58 Zhongshan Road 2, Guangzhou, 510080, P.R. China.
Quanyuan ShanDepartment of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound , The First Affiliated Hospital of Sun Yat-sen University, No.58 Zhongshan Road 2, Guangzhou, 510080, P.R. China.
Xiaoyan XieDepartment of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound , The First Affiliated Hospital of Sun Yat-sen University, No.58 Zhongshan Road 2, Guangzhou, 510080, P.R. China.
Luyao ZhouDepartment of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound , The First Affiliated Hospital of Sun Yat-sen University, No.58 Zhongshan Road 2, Guangzhou, 510080, P.R. China.
The First Affiliated Hospital, Sun Yat-sen University · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To explore an effective noninvasive tool for monitoring liver fibrosis of children with biliary atresia (BA) is important but evidences are limited. This study is to investigate the predictive accuracy of supersonic shearwave elastography (SSWE) in liver fibrosis for postoperative patients with BA and to compare it with aspartate aminotransferase to platelet ratio index (APRI) and fibrosis-4 (FIB-4). 24 patients with BA received SSWE and laboratory tests before scheduled for liver biopsy. Spearman rank coefficient and receiver operating characteristic (ROC) were used to analyze data. Metavir scores were F0 in 3, F1 in 2, F2 in 4, F3 in 7 and F4 in 8 patients. FIB-4 failed to correlate with fibrosis stage. The areas under the ROC curves of SSWE, APRI and their combination were 0.79, 0.65 and 0.78 for significant fibrosis, 0.81, 0.64 and 0.76 for advanced fibrosis, 0.82, 0.56 and 0.84 for cirrhosis. SSWE values at biopsy was correlated with platelet count (r = -0.426, P = 0.038), serum albumin (r = -0.670, P < 0.001), total bilirubin (r = 0.419, P = 0.041) and direct bilirubin levels (r = 0.518, P = 0.010) measured at 6 months after liver biopsy. Our results indicate that SSWE is a more promising tool to assess liver fibrosis than APRI and FIB-4 in children with BA.

Indexed as

Biliary AtresiaBlood Chemical AnalysisDiagnostic Tests, RoutineElasticity Imaging TechniquesHumansLiver CirrhosisROC Curve

Identifiers

PMID27511435
PMCPMC4980634
OpenAlexW2517082172

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.