Evidence map›Paper›PMID 27511188›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2017

The value of

Peter S N van Rossum, David V Fried, Lifei Zhang, Wayne L Hofstetter, Linus Ho, Gert J Meijer, Brett W Carter, Laurence E Court, Steven H Lin

Abstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Cancer imaging : the official publication of the International Cancer Imaging Society · 2026
    Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Frontiers in oncology · 2020
    Article
  10. Article
  11. Article
  12. Prognostic values of mid-radiotherapyRadiation oncology (London, England) · 2019
    Article
  13. Article
  14. European journal of nuclear medicine and molecular imaging · 2018
    Article
  15. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2017
    Article
  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Peter S N van RossumDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA. P.S.N.vanRossum-2@umcutrecht.nl.
David V FriedDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Lifei ZhangDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Wayne L HofstetterDepartment of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Linus HoDepartment of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Gert J MeijerDepartment of Radiation Oncology, University Medical Center Utrecht, PO Box 85500, Q00.3.11, 3508GA, Utrecht, The Netherlands.
Brett W CarterDepartment of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Laurence E CourtDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Steven H LinDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA. SHLin@mdanderson.org.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

purposeThe purpose of our study was to determine the value of

methodsIn 70 consecutive patients receiving a three-step treatment strategy of induction chemotherapy and preoperative chemoradiotherapy for oesophageal adenocarcinoma,

resultsA poor pathologic response after induction chemotherapy and preoperative CRT was found in 27 patients (39 %). Patients with a poor pathologic response experienced less of a reduction in TLG after induction chemotherapy (p < 0.01). The change in TLG was predictive for a poor pathologic response at a threshold of -26 % (sensitivity 67 %, specificity 84 %, accuracy 77 %, PPV 72 %, NPV 80 %), yielding an area-under-the-curve of 0.74 in ROC analysis. Also, patients with a decrease in TLG lower than 26 % had a significantly worse PFS (p = 0.02), but not OS (p = 0.18).

conclusions

Indexed as

AdenocarcinomaAntineoplastic AgentsChemoradiotherapy, AdjuvantDisease-Free SurvivalEarly Detection of CancerEsophageal NeoplasmsFemaleFluorodeoxyglucose F18HumansInduction ChemotherapyLongitudinal StudiesMaleMiddle AgedPositron-Emission TomographyPreoperative CarePrognosisAntineoplastic AgentsFluorodeoxyglucose F18Radiopharmaceuticals18F-FDG PETChemoradiotherapyChemotherapyOesophageal cancerTreatment response

Identifiers

PMID27511188
PMCPMC5121174

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.