ArticleHypertension research : official journal of the Japanese Society of Hypertension2017
Mesenchymal-to-epithelial transition in the placental tissues of patients with preeclampsia.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- First-trimester multi-modal cell-free DNA analysis for prediction of preterm and term preeclampsia.AJOG global reports · 2026Article
- Evaluating valaciclovir, letermovir, and maribavir safety in first-trimester human placental development.Scientific reports · 2026Article
- Leveraging PANoptosis-associated genes for unraveling implication of decidualization deficiency in pre-eclampsia via transcriptome data and experiment validation.Frontiers in cell and developmental biology · 2026Article
- Role of circular RNAs in preeclampsia (Review).Experimental and therapeutic medicine · 2024Review
- AC092100.1 promotes angiogenesis in pre-eclampsia through YTHDC2/VEGFA signaling.Functional & integrative genomics · 2024Article
- Epithelial-mesenchymal transition in tissue repair and degeneration.Nature reviews. Molecular cell biology · 2024Review
- Impact of interaction between individual genomes and preeclampsia on the severity of autism spectrum disorder symptoms.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Article
- Placental transcriptomic signatures of prenatal and preconceptional maternal stress.Molecular psychiatry · 2024Article
- Maternal circulating miRNAs contribute to negative pregnancy outcomes by altering placental transcriptome and fetal vascular dynamics.PloS one · 2023Article
- Regulators involved in trophoblast syncytialization in the placenta of intrauterine growth restriction.Frontiers in endocrinology · 2023Review
- Preeclampsia and Fetal Growth Restriction as Risk Factors of Future Maternal Cardiovascular Disease-A Review.Journal of clinical medicine · 2022Review
- THBS1 regulates trophoblast fusion through a CD36-dependent inhibition of cAMP, and its upregulation participates in preeclampsia.Genes & diseases · 2021Article
- miRNAs and Their Gene Targets-A Clue to Differentiate Pregnancies with Small for Gestational Age Newborns, Intrauterine Growth Restriction, and Preeclampsia.Diagnostics (Basel, Switzerland) · 2021Article
- [ALKBH5 suppresses migration and invasion of human trophoblast cells by inhibiting epithelial-mesenchymal transition].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- Review
- ROS/p53/miR‑335‑5p/Sp1 axis modulates the migration and epithelial to mesenchymal transition of JEG‑3 cells.Molecular medicine reports · 2020Article
- The potential role of pregnancy-associated plasma protein-A2 in angiogenesis and development of preeclampsia.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Maternal circulating miRNAs that predict infant FASD outcomes influence placental maturation.Life science alliance · 2019Article
- Impairment of BKca channels in human placental chorionic plate arteries is potentially relevant to the development of preeclampsia.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During early pregnancy in humans, mesenchymal-to-epithelial transition (MET) contributes to decidualization of endometrial stromal cells in the uterus. Defects in decidualization can interfere with placental formation and can lead to pregnancy complications, including preeclampsia. However, MET markers in preeclamptic placental tissues have not been characterized. To investigate the association between changes in MET and preeclampsia, we evaluated MET markers in preeclamptic placental tissues relative to normal placentas. Placentas were collected from 20 preeclamptic and 20 normotensive healthy women. Protein and mRNA levels of MET-related markers, including E-cadherin, N-cadherin (neural cadherin), vimentin, ZO-1 (zona occludens 1) and SLUG, were analyzed via western blot and quantitative real-time PCR (Q-PCR), respectively. E- and N-cadherin were localized in the placentas through immunohistochemistry. The mRNA and protein expressions of GLI1 and GLI2 were detected by Q-PCR and western blot. In preeclamptic placentas, the mRNA and protein levels of E-cadherin and ZO-1 were elevated relative to the controls, whereas the levels of N-cadherin, SLUG and vimentin were lower. The staining intensities of E- and N-cadherin were consistent with their protein levels detected by western blot. The mRNA and protein levels of GLI1 and GLI2 were significantly lower in preeclamptic placentas compared with that in control placentas. We conclude that MET in the placenta may be associated with the progression of preeclampsia.
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