ArticleThe Journal of physiology2016
Carotid sinus denervation ameliorates renovascular hypertension in adult Wistar rats.
Article in The Journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 47 citations in OpenAlex.
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- Immunohistochemical Detection of PIEZO Ion Channels in the Human Carotid Sinus and Carotid Body.Biomolecules · 2025Article
- Commonalities and differences in carotid body dysfunction in hypertension and heart failure.The Journal of physiology · 2023Article
- Carotid body: an emerging target for cardiometabolic co-morbidities.Experimental physiology · 2023Review
- The sympathetic nervous system exacerbates carotid body sensitivity in hypertension.Cardiovascular research · 2023Article
- Role of Vascular Receptors in the Development of Hypertension in the Elderly Population.The International journal of angiology : official publication of the International College of Angiology, Inc · 2022Article
- The carotid body: A novel key player in neuroimmune interactions.Frontiers in immunology · 2022Review
- Carotid body chemoreceptors: physiology, pathology, and implications for health and disease.Physiological reviews · 2021Review
- Antihypertensive Effects ofNutrients · 2020Article
- Endogenous hydrogen sulfide maintains eupnea in an in situ arterially perfused preparation of rats.Communications biology · 2020Article
- Neuronal Networks in Hypertension: Recent Advances.Hypertension (Dallas, Tex. : 1979) · 2020Review
- Impaired Autonomic Nervous System-Microbiome Circuit in Hypertension.Circulation research · 2019Review
- Pre- and post-inspiratory neurons change their firing properties in female rats exposed to chronic intermittent hypoxia.Neuroscience · 2019Article
- Importance of the commissural nucleus of the solitary tract in renovascular hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Carotid bodies contribute to sympathoexcitation induced by acute salt overload.Experimental physiology · 2019Article
- Rostral Ventrolateral Medulla and Hypertension.Hypertension (Dallas, Tex. : 1979) · 2018Review
- An Immune System-Modified Rat Model for Human Stem Cell Transplantation Research.Stem cell reports · 2018Article
- Interdependent feedback regulation of breathing by the carotid bodies and the retrotrapezoid nucleus.The Journal of physiology · 2018Review
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9 authors at 5 institutions in 4 countries.
Funding
Abstract
key pointsPeripheral chemoreflex sensitization is a feature of renovascular hypertension. Carotid sinus nerve denervation (CSD) has recently been shown to relieve hypertension and reduce sympathetic activity in other rat models of hypertension. We show that CSD in renovascular hypertension halts further increases in blood pressure. Possible mechanisms include improvements in baroreceptor reflex sensitivity and renal function, restoration of cardiac calcium signalling towards control levels, and reduced neural inflammation. Our data suggest that the peripheral chemoreflex may be a viable therapeutic target for renovascular hypertension. ABSTRACT: The peripheral chemoreflex is known to be hyper-responsive in both spontaneously hypertensive (SHR) and Goldblatt hypertensive (two kidney one clip; 2K1C) rats. We have previously shown that carotid sinus nerve denervation (CSD) reduces arterial blood pressure (ABP) in SHR. In the present study, we show that CSD ameliorates 2K1C hypertension and reveal the potential underlying mechanisms. Adult Wistar rats were instrumented to record ABP via telemetry, and then underwent CSD (n = 9) or sham CSD (n = 9) 5 weeks after renal artery clipping, in comparison with normal Wistar rats (n = 5). After 21 days, renal function was assessed, and tissue was collected to assess sympathetic postganglionic intracellular calcium transients ([Ca
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.