ArticleMolecular medicine reports2016
FSH aggravates bone loss in ovariectomised rats with experimental periapical periodontitis.
Article in Molecular medicine reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Increased Prevalence of Periapical Lesions in Osteoporosis Patients: A Systematic Review.European endodontic journal · 2025Pooled it
- Effects of ovariectomy-induced osteoporosis and two photobiomodulation protocols on the repair of apical periodontitis in Wistar rats: A microCT study.International endodontic journal · 2025Article
- Interaction between apical periodontitis and systemic disease (Review).International journal of molecular medicine · 2023Review
- Periapical status in patients affected by osteoporosis: A retrospective clinical study.Clinical and experimental dental research · 2022Article
- Roles of Follicle-Stimulating Hormone on Bone Metabolism in Late Postmenopausal Women.Journal of bone metabolism · 2022Article
- Serum FSH Is Associated With BMD, Bone Marrow Adiposity, and Body Composition in the AGES-Reykjavik Study of Older Adults.The Journal of clinical endocrinology and metabolism · 2021Observational
- Follicle-stimulating hormone impairs dental pulp stem cells odontogenic differentiation.Journal of cellular and molecular medicine · 2020Article
- A Follicle-Stimulating Hormone Exacerbates the Progression of Periapical Inflammation Through Modulating the Cytokine Release in Periodontal Tissue.Inflammation · 2020Article
- Roles of follicle stimulating hormone and its receptor in human metabolic diseases and cancer.American journal of translational research · 2020Review
- Estrogen deficiency aggravates apical periodontitis by regulating NLRP3/caspase-1/IL-1β axis.American journal of translational research · 2020Article
- Modulation of Gonadotropins Activity by Antibodies.Frontiers in endocrinology · 2019Review
- Extragonadal Actions of FSH: A Critical Need for Novel Genetic Models.Endocrinology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periapical bone loss is one of the prominent pathological and clinical features of periapical periodontitis. Previous studies have demonstrated that follicle‑stimulating hormone (FSH) could directly affect skeletal remodelling by stimulating the formation and the function of osteoclasts in vitro and in vivo. However, the effect of FSH on periapical bone loss remained to be fully elucidated. In the current study, a rat model was established in order to verify the effect of FSH in experimental periapical lesions. It was identified that FSH aggravated the bone loss of periapical lesions. In addition, RANKL‑, TRAP‑, TNF‑α‑ and IL‑1β‑positive cells were increased significantly in FSH‑treated groups, which indicated that the function of FSH in bone loss may be mediated through the increasing activity of osteoclasts and the increased secretion of inflammatory cytokines. The results of the current study suggested that FSH, independent of oestrogen, may aggravate periapical bone loss by FSH receptors, which may serve an important role in the immune and inflammatory response of the host to root canal and periradicular infection during menopause.
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Registered trials
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