Evidence map›Paper›PMID 27510540›Full record

ArticleThe American journal of clinical nutrition2016

Sweet-beverage consumption and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC).

Eva M Navarrete-Muñoz, Petra A Wark, Dora Romaguera, Nirmala Bhoo-Pathy, Dominique Michaud, Esther Molina-Montes, Anne Tjønneland, Anja Olsen, Kim Overvad, Marie-Christine Boutron-Ruault and 31 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 6 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 6 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
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  15. Sugary drinks and cancer risk.Translational cancer research · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors at 20 institutions in 14 countries.

Eva M Navarrete-MuñozDepartment of Public Health, Faculty of Medicine, Miguel Hernández University, Alicante, Spain; The Spanish Biomedical Research Centre in Epidemology and Public Health (CIBERESP), Health Institute Carlos III, Madrid, Spain;
Petra A WarkGlobal eHealth Unit, Department of Primary Care and Public Health.
Dora RomagueraDepartment of Epidemiology and Biostatistics, and The Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBEROBN), Health Institute Carlos III, Madrid, Spain; Medical Research Institute of Palma, University Hospital Son Espases, Palma de Mallorca, Spain; mariaadoracion.romaguera@ssib.es.
Nirmala Bhoo-PathyJulius Centre University of Malaya, Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia;
Dominique MichaudDepartment of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA;
Esther Molina-MontesThe Spanish Biomedical Research Centre in Epidemology and Public Health (CIBERESP), Health Institute Carlos III, Madrid, Spain; Andalusian School of Public Health. Biomedical Research Institute of Granada; University Hospital of Granada/Granada University, Granada, Spain;
Anne TjønnelandDiet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen Ø, Denmark;
Anja OlsenDiet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen Ø, Denmark;
Kim OvervadDepartment of Public Health, Section for Epidemiology, Aarhus University, Aarhus C, Denmark;
Marie-Christine Boutron-RuaultCentre for Research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, National Institute for Health and Medical Research, Villejuif, France; UMRS 1018, Université Paris Sud, Villejuif, France; Institut Gustave Roussy, Villejuif, France;
Françoise Clavel-ChapelonCentre for Research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, National Institute for Health and Medical Research, Villejuif, France; UMRS 1018, Université Paris Sud, Villejuif, France; Institut Gustave Roussy, Villejuif, France;
Guy FagherazziCentre for Research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, National Institute for Health and Medical Research, Villejuif, France; UMRS 1018, Université Paris Sud, Villejuif, France; Institut Gustave Roussy, Villejuif, France;
Verena A KatzkeDivision of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany;
Tilman KühnDivision of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany;
Annika SteffenDepartment of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany;
Antonia TrichopoulouHellenic Health Foundation, Athens, Greece; Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece;
Eleni KlinakiHellenic Health Foundation, Athens, Greece;
Eleni-Maria PapatestaHellenic Health Foundation, Athens, Greece;
Giovanna MasalaMolecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, Florence, Italy;
Vittorio KroghEpidemiology and Prevention Unit. Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy;
Rosario TuminoCancer Registry and Histopathology Unit, "Civic - M.P. Arezzo" Hospital, ASP Ragusa, Italy;
Alessio NaccaratiHuman Genetics Foundation,Torino, Molecular and Genetic Epidemiology Unit, Torino, Italy;
Amalia MattielloDipartamento di Medicina Clinica e Chirurgia, Federico II University of Naples, Naples, Italy;
Petra H PeetersMRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Netherlands;
Charlotta RylanderDepartment of Community Medicine, University of Tromsø-the Arctic University of Norway, Tromsø, Norway;
Christine L ParrDepartment of Chronic Diseases, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway;
Guri SkeieDepartment of Community Medicine, University of Tromsø-the Arctic University of Norway, Tromsø, Norway;
Elisabete WeiderpassDepartment of Community Medicine, University of Tromsø-the Arctic University of Norway, Tromsø, Norway; Department of Research, Cancer Registry of Norway, Oslo, Norway; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden; Samfundet Folkhälsan, Helsinki, Finland;
J Ramón QuirósPublic Health Directorate, Asturias, Spain;
Eric J DuellUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute, Catalan Institute of Oncology, Barcelona, Spain;
Miren DorronsoroThe Spanish Biomedical Research Centre in Epidemology and Public Health (CIBERESP), Health Institute Carlos III, Madrid, Spain; Public Health Direction Biodonostia Basque Regional Health Department, San Sebastian, Spain;
José María HuertaThe Spanish Biomedical Research Centre in Epidemology and Public Health (CIBERESP), Health Institute Carlos III, Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain;
Eva ArdanazThe Spanish Biomedical Research Centre in Epidemology and Public Health (CIBERESP), Health Institute Carlos III, Madrid, Spain; Navarre Public Health Institute, Pamplona, Spain;
Nick WarehamMedical Research Council Epidemiology Unit.
Kay-Tee KhawDepartment of Public Health and Primary Care, and Clinical Gerontology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom;
Ruth C TravisCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom;
Tim KeyCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom;
Magdalena StepienNutrition and Metabolism Section, International Agency for Research on Cancer, Lyon, France;
Heinz FreislingDepartment for Determinants of Chronic Diseases, National Institute for Public Health and the Environment, Bilthoven, Netherlands; and.
Elio RiboliDepartment of Epidemiology and Biostatistics, and.
H Bas Bueno-de-MesquitaDepartment of Epidemiology and Biostatistics, and Julius Centre University of Malaya, Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Department for Determinants of Chronic Diseases, National Institute for Public Health and the Environment, Bilthoven, Netherlands; and Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, Netherlands.
Université Paris-Sud · FRDanish Cancer Society · DKGerman Cancer Research Center · DEHellenic Health Foundation · GRUiT The Arctic University of Norway · NOUniversitat de Miguel Hernández d'Elx · ESUniversity of Oxford · GBAarhus University · DKAcademy of Athens · GRAzienda Usl 8 Arezzo · ITBasque Government · ESCambridge School · PTCancer Registry of Norway · NOCancer Research And Biostatistics · USCentre international de recherche sur le cancer · FRFederico II University Hospital · ITFondazione IRCCS Istituto Nazionale dei Tumori · ITGerman Institute of Human Nutrition · DEGobierno del Principado de Asturias · ESInstitute of Cancer Research · CA

Funding

Cancer Research UK 14136Cancer Research UK 16491Medical Research Council G0401527Medical Research Council G1000143Medical Research Council MR/N003284/1World Health Organization 001
6 · The paper itself

Abstract

backgroundThe consumption of sweet beverages has been associated with greater risk of type 2 diabetes and obesity, which may be involved in the development of pancreatic cancer. Therefore, it has been hypothesized that sweet beverages may increase pancreatic cancer risk as well.

objectiveWe examined the association between sweet-beverage consumption (including total, sugar-sweetened, and artificially sweetened soft drink and juice and nectar consumption) and pancreatic cancer risk.

designThe study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort. A total of 477,199 participants (70.2% women) with a mean age of 51 y at baseline were included, and 865 exocrine pancreatic cancers were diagnosed after a median follow-up of 11.60 y (IQR: 10.10-12.60 y). Sweet-beverage consumption was assessed with the use of validated dietary questionnaires at baseline. HRs and 95% CIs were obtained with the use of multivariable Cox regression models that were stratified by age, sex, and center and adjusted for educational level, physical activity, smoking status, and alcohol consumption. Associations with total soft-drink consumption were adjusted for juice and nectar consumption and vice versa.

resultsTotal soft-drink consumption (HR per 100 g/d: 1.03; 95% CI: 0.99, 1.07), sugar-sweetened soft-drink consumption (HR per 100 g/d: 1.02; 95% CI: 0.97, 1.08), and artificially sweetened soft-drink consumption (HR per 100 g/d: 1.04; 95% CI: 0.98, 1.10) were not associated with pancreatic cancer risk. Juice and nectar consumption was inversely associated with pancreatic cancer risk (HR per 100 g/d: 0.91; 95% CI: 0.84, 0.99); this association remained statistically significant after adjustment for body size, type 2 diabetes, and energy intake.

conclusionsSoft-drink consumption does not seem to be associated with pancreatic cancer risk. Juice and nectar consumption might be associated with a modest decreased pancreatic cancer risk. Additional studies with specific information on juice and nectar subtypes are warranted to clarify these results.

Indexed as

AdenocarcinomaBeveragesCarbonated BeveragesCohort StudiesDietary CarbohydratesEuropeFemaleFollow-Up StudiesFruit and Vegetable JuicesFunctional FoodHumansIncidenceMalePancreatic NeoplasmsPrevalenceProportional Hazards ModelsDietary CarbohydratesSweetening Agentsepidemiologyjuice and nectarpancreatic cancerpreventionrisk factorssoft drinkssugary drinkssweet beverages

Identifiers

PMID27510540
PMCPMC6241849
OpenAlexW2499651799

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.