Evidence map›Paper›PMID 27510504›Full record

ArticleMolecular neurobiology2017

Higher Vulnerability of Menadione-Exposed Cortical Astrocytes of Glutaryl-CoA Dehydrogenase Deficient Mice to Oxidative Stress, Mitochondrial Dysfunction, and Cell Death: Implications for the Neurodegeneration in Glutaric Aciduria Type I.

Marília Danyelle Nunes Rodrigues, Bianca Seminotti, Ângela Zanatta, Aline de Mello Gonçalves, Bruna Bellaver, Alexandre Umpierrez Amaral, André Quincozes-Santos, Stephen Irwin Goodman, Michael Woontner, Diogo Onofre Souza and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Marília Danyelle Nunes RodriguesDepartamento e PPG Bioquímica, ICBS/Universidade Federal do Rio Grande do Sul (UFRGS), Rua Ramiro Barcelos N° 2600, Anexo, Porto Alegre, RS, CEP90035-003, Brazil.
Bianca SeminottiDepartamento e PPG Bioquímica, ICBS/Universidade Federal do Rio Grande do Sul (UFRGS), Rua Ramiro Barcelos N° 2600, Anexo, Porto Alegre, RS, CEP90035-003, Brazil.
Ângela ZanattaDepartamento e PPG Bioquímica, ICBS/Universidade Federal do Rio Grande do Sul (UFRGS), Rua Ramiro Barcelos N° 2600, Anexo, Porto Alegre, RS, CEP90035-003, Brazil.
Aline de Mello GonçalvesDepartamento e PPG Bioquímica, ICBS/Universidade Federal do Rio Grande do Sul (UFRGS), Rua Ramiro Barcelos N° 2600, Anexo, Porto Alegre, RS, CEP90035-003, Brazil.
Bruna BellaverDepartamento e PPG Bioquímica, ICBS/Universidade Federal do Rio Grande do Sul (UFRGS), Rua Ramiro Barcelos N° 2600, Anexo, Porto Alegre, RS, CEP90035-003, Brazil.
Alexandre Umpierrez AmaralDepartamento e PPG Bioquímica, ICBS/Universidade Federal do Rio Grande do Sul (UFRGS), Rua Ramiro Barcelos N° 2600, Anexo, Porto Alegre, RS, CEP90035-003, Brazil.
André Quincozes-SantosDepartamento e PPG Bioquímica, ICBS/Universidade Federal do Rio Grande do Sul (UFRGS), Rua Ramiro Barcelos N° 2600, Anexo, Porto Alegre, RS, CEP90035-003, Brazil.
Stephen Irwin GoodmanDepartment of Pediatrics, University of Colorado Denver, Aurora, CO, USA.
Michael WoontnerDepartment of Pediatrics, University of Colorado Denver, Aurora, CO, USA.
Diogo Onofre SouzaDepartamento e PPG Bioquímica, ICBS/Universidade Federal do Rio Grande do Sul (UFRGS), Rua Ramiro Barcelos N° 2600, Anexo, Porto Alegre, RS, CEP90035-003, Brazil.
Moacir WajnerDepartamento e PPG Bioquímica, ICBS/Universidade Federal do Rio Grande do Sul (UFRGS), Rua Ramiro Barcelos N° 2600, Anexo, Porto Alegre, RS, CEP90035-003, Brazil. mwajner@ufrgs.br.
Universidade Federal do Rio Grande do Sul · BRUniversity of Colorado Denver · USHospital de Clínicas de Porto Alegre · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients affected by glutaric aciduria type I (GA-I) show progressive cortical leukoencephalopathy whose pathogenesis is poorly known. In the present work, we exposed cortical astrocytes of wild-type (Gcdh

Indexed as

Amino Acid Metabolism, Inborn ErrorsAnimalsAntioxidantsAstrocytesBrain Diseases, MetabolicCell DeathCell SurvivalCerebral CortexFluoresceinsGlutaryl-CoA DehydrogenaseGlutathione PeroxidaseInflammation MediatorsMembrane Potential, MitochondrialMiceMitochondriaNerve Degeneration2',7'-dichlorodihydrofluoresceinAntioxidantsFluoresceinsGlutaryl-CoA DehydrogenaseGlutathione PeroxidaseInflammation MediatorsNitric OxideReactive Oxygen SpeciesSuperoxide DismutaseVitamin K 3Gcdh −/− mice astrocytesGlutaric aciduria type IMitochondrial dysfunctionOxidative stressPro-inflammatory response

Identifiers

PMID27510504
OpenAlexW2477953890

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.