Evidence map›Paper›PMID 27510494›Full record

ArticleSocial cognitive and affective neuroscience2016

The role of the dorsolateral prefrontal cortex in early threat processing: a TMS study.

Laura Sagliano, Francesca D'Olimpio, Francesco Panico, Serena Gagliardi, Luigi Trojano

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Social cognitive and affective neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06900959 (Transcranial Static Field Stimulation), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06900959 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Transcranial Static Field Stimulation (tSMS) and Transcranial Direct Current Stimulation (tDCS) for the Treatment of Neurological Symptoms

TypeinterventionalSponsorNeuromed IRCCSRan2025 to 2026Enrolled40ConditionsNeurological Diseases or ConditionsArmstranscranial static field stimulation (tSMS) and transcranial (tDCS)
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 50 citations in OpenAlex.

  1. Trial
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  3. Article
  4. Trait-related neural basis of attentional bias to emotions: a tDCS study.Cognitive, affective & behavioral neuroscience · 2023
    Article
  5. Article
  6. Article
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  9. Prefrontal cortical activation during working memory task anticipation contributes to discrimination between bipolar and unipolar depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
    Article
  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Laura SaglianoDepartment of Psychology, Second University of Naples, Viale Ellittico 31, Caserta, 81100, Italy laurasagliano@gmail.com.
Francesca D'OlimpioDepartment of Psychology, Second University of Naples, Viale Ellittico 31, Caserta, 81100, Italy.
Francesco PanicoDepartment of Psychology, Second University of Naples, Viale Ellittico 31, Caserta, 81100, Italy.
Serena GagliardiDepartment of Psychology, Second University of Naples, Viale Ellittico 31, Caserta, 81100, Italy.
Luigi TrojanoDepartment of Psychology, Second University of Naples, Viale Ellittico 31, Caserta, 81100, Italy.
University of Campania "Luigi Vanvitelli" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies demonstrated that excitatory (high frequency) offline transcranial magnetic stimulation (TMS) over the left and right dorsolateral prefrontal cortex (DLPFC) modulates attention allocation on threatening stimuli in non-clinical samples. These studies only employed offline TMS protocol that did not allow investigating the effect of the stimulation on the early stage of threat processing. In this study, the role of the right and left dorsolateral prefrontal cortex in early threat processing was investigated in high and low anxious individuals by means of an inhibitory single-pulse online TMS protocol. Our results demonstrated the role of the left DLPFC in an early stage of threat processing and that this effect is modulated by individuals' anxiety level. The inhibitory stimulation of the left DLPFC determined a disengagement bias in high anxious individuals, while the same stimulation determined an attentional avoidance in low anxious individuals. The findings of the present study suggest that right and left DLPFC are differently involved in early threat processing of healthy individuals.

Indexed as

AdultAnxietyAttentionFemaleHumansJudgmentPrefrontal CortexTranscranial Magnetic StimulationYoung AdultanxietyattentionDLPFCthreatTMS

Identifiers

PMID27510494
PMCPMC5141957
OpenAlexW2500672275

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.