ArticleMicrocirculation (New York, N.Y. : 1994)2016
Microvascular hemodynamics in the chick chorioallantoic membrane.
Article in Microcirculation (New York, N.Y. : 1994), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- In vivo high-speed microscopy of microbubbles in the chorioallantoic membrane model.Theranostics · 2024Article
- Review
- Catechin reduces phototoxic effects induced by protoporphyrin IX-based photodynamic therapy in the chick embryo chorioallantoic membrane.Journal of biomedical optics · 2020Article
- Novel morphometric analysis of higher order structure of human radial peri-papillary capillaries: relevance to retinal perfusion efficiency and age.Scientific reports · 2019Article
- Chick Embryo: A Preclinical Model for Understanding Ischemia-Reperfusion Mechanism.Frontiers in pharmacology · 2018Article
- An angiogenesis platform using a cubic artificial eggshell with patterned blood vessels on chicken chorioallantoic membrane.PloS one · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveThe microvasculature of the CAM in the developing chick embryo is characterized by interdigitating arteriolar and venular trees, connected at multiple points along their lengths to a mesh-like capillary plexus. Theoretical modeling techniques were employed to investigate the resulting hemodynamic characteristics of the CAM.
methodsBased on previously obtained anatomical data, a model was developed in which the capillary plexus was treated as a porous medium. Supply of blood from arterioles and drainage into venules were represented by distributions of flow sources and sinks. Predicted flow velocities were compared with measurements in arterioles and venules obtained via video microscopy.
resultsIf it was assumed that blood flowed into and out of the capillary plexus only at the ends of terminal arterioles and venules, the predicted velocities increased with decreasing diameter in vessels below 50 μm in diameter, contrary to the observations. Distributing sources/sinks along arterioles/venules led to velocities consistent with the data.
conclusionsThese results imply that connections to the capillary plexus distributed along the arterioles and venules strongly affect the hemodynamic characteristics of the CAM. The theoretical model provides a basis for quantitative simulations of structural adaptation in CAM networks in response to hemodynamic stimuli.
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Registered trials
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