Evidence map›Paper›PMID 27510330›Full record

ReviewPharmacology & therapeutics2017

Pericytes for the treatment of orthopedic conditions.

Aaron W James, Paul Hindle, Iain R Murray, Christopher C West, Tulyapruek Tawonsawatruk, Jia Shen, Greg Asatrian, Xinli Zhang, Vi Nguyen, A Hamish Simpson and 3 more

Open access · greenAbstract readReview
In one paragraph

Review in Pharmacology & therapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
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  19. Article
  20. Enrichment of CD146Theranostics · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Aaron W JamesSchool of Dentistry, University of California, Los Angeles, United States; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, United States; Orthopedic Hospital Research Center, University of California, Los Angeles, United States; Department of Pathology, Johns Hopkins University, Baltimore, MD, United States. Electronic address: awjames@jhmi.edu.
Paul HindleDepartment of Trauma and Orthopaedic Surgery, The University of Edinburgh, Edinburgh, United Kingdom.
Iain R MurrayDepartment of Trauma and Orthopaedic Surgery, The University of Edinburgh, Edinburgh, United Kingdom; BHF Center for Vascular Regeneration & MRC Center for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Christopher C WestBHF Center for Vascular Regeneration & MRC Center for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom; Department of Plastic and Reconstructive Surgery, St. Johns Hospital, Livingston, United Kingdom.
Tulyapruek TawonsawatrukDepartment of Trauma and Orthopaedic Surgery, The University of Edinburgh, Edinburgh, United Kingdom; BHF Center for Vascular Regeneration & MRC Center for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom; Department of Orthopaedics, Ramathibodi Hospital, Madihol University, Thailand.
Jia ShenSchool of Dentistry, University of California, Los Angeles, United States.
Greg AsatrianSchool of Dentistry, University of California, Los Angeles, United States.
Xinli ZhangSchool of Dentistry, University of California, Los Angeles, United States.
Vi NguyenDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, United States.
A Hamish SimpsonDepartment of Trauma and Orthopaedic Surgery, The University of Edinburgh, Edinburgh, United Kingdom.
Kang TingSchool of Dentistry, University of California, Los Angeles, United States.
Bruno PéaultOrthopedic Hospital Research Center, University of California, Los Angeles, United States; BHF Center for Vascular Regeneration & MRC Center for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Chia SooOrthopedic Hospital Research Center, University of California, Los Angeles, United States; Department of Surgery, University of California, Los Angeles, Los Angeles, CA, United States.
University of California, Los Angeles · USMRC Centre for Regenerative Medicine · GBOrthopaedic Hospital · USUniversity of Edinburgh · GB

Funding

NELL-1 Systemic Therapy for OsteoporosisR01AR066782 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EASLEY, JEREMIAH, TING, KANG · 2014 to 2018
$2.0M
Wnt and PPARy Signaling in Nell-1 and BMP2 Mediated Bone RegenerationR01AR061399 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SOO, CHIA · 2012 to 2016
$1.7M
NELL-1 isoforms for the systemic treatment of osteoporosisK08AR068316 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JAMES, AARON W · 2015 to 2019
$534k
Chief Scientist Office CAF/11/13Medical Research Council G1000816NIAMS NIH HHS K08 AR068316NIAMS NIH HHS R01 AR061399NIAMS NIH HHS R01 AR066782Wellcome Trust 097483
6 · The paper itself

Abstract

Pericytes and other perivascular stem cells are of growing interest in orthopedics and tissue engineering. Long regarded as simple regulators of angiogenesis and blood pressure, pericytes are now recognized to have MSC (mesenchymal stem cell) characteristics, including multipotentiality, self-renewal, immunoregulatory functions, and diverse roles in tissue repair. Pericytes are typified by characteristic cell surface marker expression (including αSMA, CD146, PDGFRβ, NG2, RGS5, among others). Although alone no marker is absolutely specific for pericytes, collectively these markers appear to selectively identify an MSC-like pericyte. The purification of pericytes is most well described as a CD146

Indexed as

AnimalsBone and BonesCartilageCell DifferentiationHumansMesenchymal Stem CellsMusculoskeletal DiseasesPericytesRodentiaStem CellsTissue EngineeringBoneCartilageMesenchymal stem cellMSCPerivascular stem cellPSC

Identifiers

PMID27510330
PMCPMC6434715
OpenAlexW2476959454

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.