Evidence map›Paper›PMID 27510316›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2017

2016 updated MASCC/ESMO consensus recommendations: Prevention of nausea and vomiting following moderately emetogenic chemotherapy.

Fausto Roila, David Warr, Paul J Hesketh, Richard Gralla, Jorn Herrstedt, Karin Jordan, Matti Aapro, Enzo Ballatori, Bernardo Rapoport

Erratum issuedAbstract readConsensus Statement
PubMed Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 4 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. 2023 updated MASCC/ESMO Consensus recommendations: Prevention of nausea and vomiting following moderately emetic risk antineoplastic agents.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
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  4. Is the addition of a neurokinin-1 receptor antagonist beneficial in moderately emetogenic chemotherapy?-a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
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  5. 5HTCancer science · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 7 countries.

Fausto RoilaMedical Oncology, Santa Maria Hospital, Via Tristano di Joannuccio 1, 05100, Terni, Italy. roila.fausto@libero.it.
David WarrCancer Clinical Research Unit, Princess Margaret Cancer Centre, Toronto, Canada.
Paul J HeskethLahey Health Cancer Institute, Burlington, USA.
Richard GrallaAlbert Einstein College of Medicine, Jacobi Medical Center, NY, USA.
Jorn HerrstedtDepartment of Oncology, Odense University, 5000, Odense, Denmark.
Karin JordanDepartment of Hematology/Oncology, Martin Luther University Halle-Wittenberg, Halle, Germany.
Matti AaproClinique de Genolier, Multidisciplinary Oncology Institute, Genolier, Switzerland.
Enzo Ballatori, Spinetoli, Italy.
Bernardo RapoportMedical Oncology Centre of Rosebank, 129 Oxford Road, Johannesburg, South Africa.
Clinique de Genolier · CHJacobi Medical Center · USMartin Luther University Halle-Wittenberg · DEOdense University Hospital · DKPrincess Margaret Cancer Centre · CASanta Maria Nuova Hospital · ITThe Medical Oncology Centre of Rosebank · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAn update of the recommendations for the prophylaxis of acute and delayed emesis induced by moderately emetogenic chemotherapy published after the last MASCC/ESMO antiemetic consensus conference in 2009 has been carried out.

methodsA systematic literature search using PubMed from January 1, 2009 to January 6, 2015 with a restriction to papers in English was conducted.

resultsOverall, two randomized phase II and seven randomized phase III studies plus the results of three subgroup analysis of large phase III trials and those of a pilot study have been included.

conclusionsIn carboplatin-treated patients, a moderate benefit from adding an NK1 receptor antagonist to dexamethasone and a 5-HT3 receptor antagonist has been shown. However, in oxaliplatin-treated patients, contrasting results about the role of NK1 receptor antagonists have been obtained. At present, it is not possible to suggest a specific 5-HT3 receptor antagonist to use for the prevention of acute emesis in these patients. No routine prophylaxis for delayed emesis is recommended but in patients receiving moderately emetogenic chemotherapy with known potential for delayed emesis (e.g., oxaliplatin, doxorubicin, cyclophosphamide) the use of dexamethasone for days 2-3 can be considered.

Indexed as

AntiemeticsAntineoplastic AgentsEmeticsHumansNauseaPilot ProjectsRandomized Controlled Trials as TopicVomitingAntiemeticsAntineoplastic AgentsEmetics5-HT3 receptor antagonistsCarboplatinIrinotecanModerately emetogenic chemotherapyNK1 receptor antagonistsOxaliplatin

Identifiers

PMID27510316
OpenAlexW2488120510

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.