Evidence map›Paper›PMID 27510286›Full record

ArticleAngewandte Chemie (International ed. in English)2016

A Synthetic Supramolecular Receptor for the Hydrosulfide Anion.

Matthew D Hartle, Ryan J Hansen, Blakely W Tresca, Samuel S Prakel, Lev N Zakharov, Michael M Haley, Michael D Pluth, Darren W Johnson

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. C-H⋯S hydrogen bonding interactions.Chemical Society reviews · 2022
    Review
  7. Hydrosulfide (HSAngewandte Chemie (International ed. in English) · 2021
    Article
  8. Article
  9. Hydrosulfide-selective ChemFETs for aqueous HSensing and Bio-Sensing Research · 2021
    Article
  10. Article
  11. Article
  12. Article
  13. Assessment of HThe Journal of biological chemistry · 2017
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Matthew D HartleDepartment of Chemistry & Biochemistry, Materials Science Institute, and Institute of Molecular Biology, University of Oregon, Eugene, OR, 97403-1253, USA.
Ryan J HansenDepartment of Chemistry & Biochemistry, Materials Science Institute, and Institute of Molecular Biology, University of Oregon, Eugene, OR, 97403-1253, USA.
Blakely W TrescaDepartment of Chemistry & Biochemistry, Materials Science Institute, and Institute of Molecular Biology, University of Oregon, Eugene, OR, 97403-1253, USA.
Samuel S PrakelDepartment of Chemistry & Biochemistry, Materials Science Institute, and Institute of Molecular Biology, University of Oregon, Eugene, OR, 97403-1253, USA.
Lev N ZakharovDepartment of Chemistry & Biochemistry, Materials Science Institute, and Institute of Molecular Biology, University of Oregon, Eugene, OR, 97403-1253, USA.
Michael M HaleyDepartment of Chemistry & Biochemistry, Materials Science Institute, and Institute of Molecular Biology, University of Oregon, Eugene, OR, 97403-1253, USA. haley@uoregon.edu.
Michael D PluthDepartment of Chemistry & Biochemistry, Materials Science Institute, and Institute of Molecular Biology, University of Oregon, Eugene, OR, 97403-1253, USA. pluth@uoregon.edu.
Darren W JohnsonDepartment of Chemistry & Biochemistry, Materials Science Institute, and Institute of Molecular Biology, University of Oregon, Eugene, OR, 97403-1253, USA. dwj@uoregon.edu.

Funding

Design of Modular Receptors for Ion and Molecule RecognitionR01GM087398 · NIGMS · UNIVERSITY OF OREGON · PI HALEY, MICHAEL MARK, JOHNSON, DARREN WILLIAM · 2010 to 2020
$2.6M
NIGMS NIH HHS R01 GM087398
6 · The paper itself

Abstract

Hydrogen sulfide (H2 S) has emerged as a crucial biomolecule in physiology and cellular signaling. Key challenges associated with developing new chemical tools for understanding the biological roles of H2 S include developing platforms that enable reversible binding of this important biomolecule. The first synthetic small molecule receptor for the hydrosulfide anion, HS(-) , using only reversible, hydrogen-bonding interactions in a series of bis(ethynylaniline) derivatives, is reported. Binding constants of up to 90 300±8700 m(-1) were obtained in MeCN. The fundamental science of reversible sulfide binding, in this case featuring a key CH⋅⋅⋅S hydrogen bond, will expand the possibility for discovery of sulfide protein targets and molecular recognition agents.

Indexed as

AnionsHydrogen BondingHydrogen SulfideKineticsMagnetic Resonance SpectroscopyMolecular ConformationReceptors, ArtificialSpectrophotometry, UltravioletAnionsHydrogen SulfideReceptors, Artificialanion bindinggasotransmittersmolecular recognitionsulfidesupramolecular chemistry

Identifiers

PMID27510286
PMCPMC5144539

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.