ArticleThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2016
Chronic respiratory disease and high altitude are associated with depressive symptoms in four diverse settings.
Article in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Associations among probiotic/prebiotic consumption, depression and chronic obstructive pulmonary disease: A cross-sectional study.Medicine · 2026Article
- [Dynamic Effects of High-Altitude Exposure on Sleep and Mood States and the Underlying Neural Mechanisms].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Article
- Associations between sugar-sweetened beverage consumption, moderate-to-vigorous-intensity physical activity levels, and depressive symptoms: a cross-sectional study based on Tibetan university students at high altitude in China.Frontiers in nutrition · 2025Article
- Disparities in the prevalence of screened depression at different altitudes in Peru: A retrospective analysis of the ENDES 2019.PloS one · 2022Article
- Sex-based changes in rat brain serotonin and behavior in a model of altitude-related vulnerability to treatment-resistant depression.Psychopharmacology · 2021Article
- Sex-Based Impact of Creatine Supplementation on Depressive Symptoms, Brain Serotonin and SSRI Efficacy in an Animal Model of Treatment-Resistant Depression.International journal of molecular sciences · 2021Article
- Prevalence of chronic obstructive pulmonary disease at high altitude: a systematic review and meta-analysis.PeerJ · 2020Article
- Association between altitude, prescription opioid misuse, and fatal overdoses.Addictive behaviors reports · 2019Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
settingDepression is a prevalent comorbidity of chronic respiratory disease (CRD), and may indicate worse clinical outcomes. The relationship between depression and living with chronic hypoxia due to CRD or residence at altitude has received little attention in resource-poor settings.
objectiveTo investigate the association between CRD conditions and depressive symptoms in four settings in Peru.
designWe collected data on CRD and depressive symptoms in adults aged ⩾35 years. Depressive symptoms were measured according to the Center for Epidemiologic Studies Depression scale. Multivariable ordinal logistic regression was used to assess the adjusted odds of being in a higher category of depressive symptoms as a function of CRD.
resultsWe analyzed data from 2953 participants (mean age 55.3 years, 49% male). The prevalence of major depressive symptoms was 19%, with significant variation according to setting. Participants with at least one CRD (OR 1.34, 95%CI 1.06-1.69) and those living at altitude (OR 1.64, 95%CI 1.10-2.43) had an increased adjusted odds of being in a higher category of depressive symptoms.
conclusionWe found a high prevalence of depressive symptoms, and a positive association between depressive symptoms with CRD and with living at altitude, both of which cause chronic hypoxia.
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