Evidence map›Paper›PMID 27510185›Full record

ArticleBreast cancer research and treatment2016

Long-term chemotherapy-induced peripheral neuropathy among breast cancer survivors: prevalence, risk factors, and fall risk.

Ting Bao, Coby Basal, Christina Seluzicki, Susan Q Li, Andrew D Seidman, Jun J Mao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer research and treatment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 204 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
204citing papers in PubMed, 8 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

204 citing papers in PubMed, 8 syntheses or guidelines pooled it, 341 citations in OpenAlex.

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  7. Diabetes mellitus as a risk factor for chemotherapy-induced peripheral neuropathy: a meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Pooled it
  8. Prevalence and risk factors of sleep disturbances in breast cancersurvivors: systematic review and meta-analyses.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
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  12. Examining the effectiveness of combination therapy in alleviating peripheral neuropathy and sleep disorders in breast cancer patients receiving chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  13. Effects of intermittent hand-foot hypothermia therapy on chemotherapy-induced peripheral neurotoxicity.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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144 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ting BaoMemorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY, 10021, USA. baot@mskcc.org.
Coby BasalMemorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY, 10021, USA.
Christina SeluzickiMemorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY, 10021, USA.
Susan Q LiMemorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY, 10021, USA.
Andrew D SeidmanMemorial Sloan Kettering Cancer Center, 300 66th Street, New York, NY, 10065, USA.
Jun J MaoMemorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY, 10021, USA.
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Estrogen Deprivation and Aromatase Inhibitor associated ArthralgiaR01CA158243 · NCI · UNIVERSITY OF PENNSYLVANIA · PI MAO, JUN J · 2011 to 2015
$2.2M
Acupuncture to Prevent Chemotherapy Dose ReductionR21CA173263 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI BAO, TING · 2013 to 2014
$349k
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA158243NCI NIH HHS R21 CA173263
6 · The paper itself

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a common toxicity associated with chemotherapy, but researchers rarely study its risk factors, fall risk, and prevalence in long-term breast cancer survivors. We aimed to determine CIPN prevalence, risk factors, and association with psychological distress and falls among long-term breast cancer survivors. We conducted Cross-sectional analyses among postmenopausal women with a history of stage I-III breast cancer who received taxane-based chemotherapy. Participants reported neuropathic symptoms of tingling/numbness in hands and/or feet on a 0-10 numerical rating scale. We conducted multivariate logistic regression analyses to evaluate risk factors associated with the presence of CIPN and the relationship between CIPN and anxiety, depression, insomnia, and patient-reported falls. Among 296 participants, 173 (58.4 %) reported CIPN symptoms, 91 (30.7 %) rated their symptoms as mild, and 82 (27.7 %) rated them moderate to severe. Compared with women of normal weight, being obese was associated with increased risk of CIPN (adjusted OR 1.94, 95 % CI: 1.03-3.65). Patients with CIPN reported greater insomnia severity, anxiety, and depression than those without (all p < 0.05). Severity of CIPN was associated with higher rates of falls, with 23.8, 31.9, and 41.5 % in the "no CIPN," "mild," and "moderate-to-severe" groups, respectively, experiencing falls (p = 0.028). The majority of long-term breast cancer survivors who received taxane-based chemotherapy reported CIPN symptoms; obesity was a significant risk factor. Those with CIPN also reported increased psychological distress and falls. Interventions need to target CIPN and comorbid psychological symptoms, and incorporate fall prevention strategies for aging breast cancer survivors.

Indexed as

Accidental FallsAdultAgedAged, 80 and overAntineoplastic AgentsBreast NeoplasmsCancer SurvivorsCross-Sectional StudiesFemaleHumansMiddle AgedPeripheral Nervous System DiseasesPostmenopausePrevalenceRisk FactorsTaxoidsAntineoplastic AgentsTaxoidsBreast cancerChemotherapyFallsObesityPeripheral neuropathy

Identifiers

PMID27510185
PMCPMC5509538
OpenAlexW2493266198

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.