Evidence map›Paper›PMID 27510160›Full record

ArticleEnvironmental science and pollution research international2016

Lead line in rodents: an old sign of lead intoxication turned into a new method for environmental surveillance.

Fellipe Augusto Tocchini de Figueiredo, Junia Ramos, Erika R Hashimoto Kawakita, Alina S Bilal, Frederico B de Sousa, William D Swaim, Joao P Mardegan Issa, Raquel F Gerlach

Abstract read
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In one paragraph

Article in Environmental science and pollution research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Fellipe Augusto Tocchini de FigueiredoDepartment of Morphology, Physiology, and Basic Pathology, School of Dentistry of Ribeirao Preto (FORP), University of Sao Paulo (USP), Avenida do Cafe S/N, Monte Alegre, Ribeirao Preto, Sao Paulo, CEP 14040-904, Brazil. fellipe.figueiredo@usp.br.
Junia RamosDepartment of Morphology, Physiology, and Basic Pathology, School of Dentistry of Ribeirao Preto (FORP), University of Sao Paulo (USP), Avenida do Cafe S/N, Monte Alegre, Ribeirao Preto, Sao Paulo, CEP 14040-904, Brazil.
Erika R Hashimoto KawakitaDepartment of Morphology, Physiology, and Basic Pathology, School of Dentistry of Ribeirao Preto (FORP), University of Sao Paulo (USP), Avenida do Cafe S/N, Monte Alegre, Ribeirao Preto, Sao Paulo, CEP 14040-904, Brazil.
Alina S BilalDepartment of Morphology, Physiology, and Basic Pathology, School of Dentistry of Ribeirao Preto (FORP), University of Sao Paulo (USP), Avenida do Cafe S/N, Monte Alegre, Ribeirao Preto, Sao Paulo, CEP 14040-904, Brazil.
Frederico B de SousaDepartment of Morphology, Science Health Center, Federal University of Paraiba (UFPB), Joao Pessoa, Paraiba, Brazil.
William D SwaimNational Institute for Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), Bethesda, MD, USA.
Joao P Mardegan IssaDepartment of Morphology, Physiology, and Basic Pathology, School of Dentistry of Ribeirao Preto (FORP), University of Sao Paulo (USP), Avenida do Cafe S/N, Monte Alegre, Ribeirao Preto, Sao Paulo, CEP 14040-904, Brazil.
Raquel F GerlachDepartment of Morphology, Physiology, and Basic Pathology, School of Dentistry of Ribeirao Preto (FORP), University of Sao Paulo (USP), Avenida do Cafe S/N, Monte Alegre, Ribeirao Preto, Sao Paulo, CEP 14040-904, Brazil.
Universidade de São Paulo · BRNational Institutes of Health · USUniversidade Federal da Paraíba · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The "lead line" was described by Henry Burton in 1840. Rodents are used as sentinels to monitor environmental pollution, but their teeth have not been used to determine lead. To determine whether lead deposits can be observed in the teeth of lead-exposed animals, since the gingival deposits known as "lead line" would likely have a correlate in the calcified tissue to which the gums are opposed during life. Male Wistar rats were exposed to lead in the drinking water (30 mg/L) since birth until 60 days-old. Molars and the incisors of each hemimandible were analyzed by scanning electron microscopy (SEM) on regular and backscattered electrons (BSE) mode. Elements were determined using electron dispersive spectroscopy (EDS). Clean cervical margins were observed on control teeth, as opposed to the findings of extensive deposits on lead-exposed animals, even in hemimandibles that had been exhumed after being buried for 90 days. BSE/EDS indicated that those deposits were an exogenous material compatible with lead sulfite. Presence of calcium, phosphorus, magnesium, carbon, lead, and oxygen is presented. Lead-exposed animals presented marked root resorption. The lead deposits characterized here for the first time show that the "lead line" seen in gums has a calcified tissue counterpart, that is detectable post-mortem even in animals exposed to a low dose of lead. This is likely a good method to detect undue lead exposure and will likely have wide application for pollution surveillance using sentinels.

Indexed as

Environmental ExposureAnimalsEnvironmental MonitoringEnvironmental PollutantsLeadMaleMicroscopy, Electron, ScanningMolarRatsRats, WistarTime FactorsEnvironmental PollutantsLeadDental enamelEnvironmental monitoringLeadLead lineSentinelsTooth

Identifiers

PMID27510160
OpenAlexW2492251868

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.