Evidence map›Paper›PMID 27510096›Full record

ReviewAntioxidants & redox signaling2017

NO

Jian Wang, S Perwez Hussain

Abstract readReview
In one paragraph

Review in Antioxidants & redox signaling, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. NOInternational journal of cancer · 2020
    Article
  4. NO control of mitochondrial function in normal and transformed cells.Biochimica et biophysica acta. Bioenergetics · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jian WangPancreatic Cancer Unit, Laboratory of Human Carcinogenesis, NIH Center for Cancer Research, National Cancer Institute , Bethesda, Maryland.
S Perwez HussainPancreatic Cancer Unit, Laboratory of Human Carcinogenesis, NIH Center for Cancer Research, National Cancer Institute , Bethesda, Maryland.
National Cancer Institute · US

Funding

Molecular Profiling of Pancreatic CancerZIABC011162 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI HUSSAIN, SYED PERWEZ · 2009 to 2023
$11.1M
Role of Inflammation in the Development and Progression of Pancreatic CancerZIABC011185 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI HUSSAIN, SYED PERWEZ · 2009 to 2023
$10.4M
6 · The paper itself

Abstract

significancePancreatic tumors express high level of nitric oxide synthases (NOSs) in particular inducible (iNOS/NOS2) and endothelial (eNOS/NOS3) forms. However, the role of nitric oxide (NO CRITICAL ISSUES: The extremely poor prognosis in pancreatic cancer is due to the late diagnosis and lack of effective therapy in advanced disease. One of the most critical issues is to decipher the underlying mechanism of disease aggressiveness and therapeutic resistance for identifying potential therapeutic target and effective treatment. Given the evidence of a strong association between inflammation and pancreatic cancer and clinical evidence, which suggests an association between NOS2 and disease aggressiveness, it is critical to define the role of NO FUTURE DIRECTIONS: Recent preclinical and clinical evidences indicate a potential therapeutic significance of targeting NO

Indexed as

AnimalsHumansMicroRNAsNeoplasm StagingNitric OxideNitric Oxide SynthasePancreatic NeoplasmsPrognosisSignal TransductionSurvival AnalysisMicroRNAsNitric OxideNitric Oxide SynthasemicroRNAnitric oxidenitric oxide synthaseNostrinpancreatic cancerpancreatic ductal adenocarcinoma (PDAC)

Identifiers

PMID27510096
PMCPMC5467115
OpenAlexW2492343697

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.