Evidence map›Paper›PMID 27509894›Full record

ArticleJournal of periodontal research2017

Sex-based differential regulation of bacterial-induced bone resorption.

M S Valerio, D S Basilakos, J E Kirkpatrick, M Chavez, J Hathaway-Schrader, B A Herbert, K L Kirkwood

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of periodontal research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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  7. Neutrophils drive sexual dimorphism in experimental periodontitis.bioRxiv : the preprint server for biology · 2024
    Article
  8. Review
  9. Review
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  11. Germ-Free C57BL/6 Mice Have Increased Bone Mass and Altered Matrix Properties but Not Decreased Bone Fracture Resistance.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023
    Article
  12. Article
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  15. Article
  16. Sexual Dimorphism in Differentiating Osteoclast Precursors Demonstrates Enhanced Inflammatory Pathway Activation in Female Cells.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021
    Article
  17. Recent Advances in Osteoclast Biological Behavior.Frontiers in cell and developmental biology · 2021
    Review
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

M S ValerioDepartment of Oral Health Sciences, The Center for Oral Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
D S BasilakosDepartment of Oral Health Sciences, The Center for Oral Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
J E KirkpatrickDepartment of Oral Health Sciences, The Center for Oral Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
M ChavezDepartment of Oral Health Sciences, The Center for Oral Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
J Hathaway-SchraderDepartment of Oral Health Sciences, The Center for Oral Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
B A HerbertDepartment of Oral Health Sciences, The Center for Oral Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
K L KirkwoodDepartment of Oral Health Sciences, The Center for Oral Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
Medical University of South Carolina · US

Funding

T-COHR: Training in Craniofacial and Oral Health ResearchT32DE017551 · NIDCR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI YAO, HAI · 2006 to 2025
$10.3M
Pilot and Feasibility Project ProgramP30GM103331 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KIRKWOOD, KEITH L · 2012 to 2016
$5.2M
Post-Transcriptional Regulation of Periodontal DiseR01DE021423 · NIDCR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KIRKWOOD, KEITH L · 2011 to 2015
$2.1M
DUSP1 and Sexual Dimorphism in PeriodontitisR21DE027017 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI KIRKWOOD, KEITH L · 2018 to 2019
$439k
The Role of MAPK-Activated Protein Kinase 2 in Periodontal DiseaseF30DE024368 · NIDCR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI HARBIN, BETHANY A. · 2014 to 2017
$156k
NIDCR NIH HHS F30 DE024368NIDCR NIH HHS R01 DE021423NIDCR NIH HHS R21 DE027017NIDCR NIH HHS T32 DE017551NIGMS NIH HHS P30 GM103331
6 · The paper itself

Abstract

BACKGROUND AND

objectivePeriodontal disease pathogenesis is comprised of the complex inflammatory immune response to oral bacterial dysbiosis. Like other inflammatory diseases, there is sexual dimorphism evident in periodontal diseases. During periodontitis, inflammatory chemokines direct neutrophils to migrate to the site of infection to neutralize the pathogen. Interestingly, these same chemokines are also involved in regulating pathogen-induced osteoclast formation. Previous reports show differences in bone turnover and lymphocyte recruitment between sexes. We hypothesize that chemokine expression is differentially regulated by sex and thus results in differential osteoclast formation. MATERIAL AND

methodsMale and female mice were utilized to isolate neutrophils based on expression of Ly6G-specific, as well as defined osteoclast progenitors. Cells were stimulated with lipopolysaccharide (LPS; 100 ng/mL) then analyzed for neutrophil infiltration and gene expression. Defined osteoclast progenitors were primed: macrophage-colony stimulating factor (25 ng/mL), receptor activator of NF-κB ligand (50 ng/mL), then stimulated with LPS. Osteoclasts were enumerated via TRAP stain and mRNA isolated for gene expression analysis via quantitative polymerase chain reaction.

resultsIn response to LPS, male neutrophils in vitro respond with increased chemokine expression and significantly more osteoclast formed in response to LPS compared to females.

conclusionsFindings support observations in humans regarding a sexual dimorphism in oral bacterial infections of alveolar bone loss. Males have a strong inflammatory response to bacterial infection, resulting in increased inflammatory microenvironment, reduced pathogenic bacteria clearance and increased osteoclast-driven bone loss in response to differential expression of key chemokines.

Indexed as

AnimalsBone ResorptionChemokinesFemaleLipopolysaccharidesMaleMiceNeutrophilsOsteoclastsPolymerase Chain ReactionSex FactorsChemokinesLipopolysaccharideschemokinesneutrophilsoral infectionsosteoclastogenesis

Identifiers

PMID27509894
PMCPMC5303566
OpenAlexW2516439018

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.