ArticlePediatric blood & cancer2016
A pilot study of parent education intervention improves early childhood development among toddlers with sickle cell disease.
Article in Pediatric blood & cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06562439 (Early Identification and Intervention Of Developmental Delay Among Infants And Toddlers With Sickle Cell Disease Using the Sickle Cell Caregiver Collaboration for Child Development), which is not on this map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Identification and Intervention Of Developmental Delay Among Infants And Toddlers With Sickle Cell Disease Using the Sickle Cell Caregiver Collaboration for Child Development (SCCCD) Intervention
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Individual-level behavioral interventions to support optimal development of children with sickle cell disease: A systematic review.Pediatric blood & cancer · 2023Pooled it
- Developmental delay in infants and toddlers with sickle cell disease: a systematic review.Developmental medicine and child neurology · 2022Pooled it
- Correlates of Cognitive Function in Sickle Cell Disease: A Meta-Analysis.Journal of pediatric psychology · 2020Pooled it
- Early Developmental Screening and a Home-Based Caregiver Intervention for Infants and Toddlers With Sickle Cell Disease: Protocol for a Prospective Mixed Methods Study.JMIR research protocols · 2026Article
- Strengthening Community-Academic Partnerships to Enhance Care for Sickle Cell Disease.OTJR : occupation, participation and health · 2026Article
- Low depression rates among caregivers of young children with sickle cell disease: a rapid report.Journal of sickle cell disease · 2026Article
- Adapting a school readiness intervention for children with sickle cell disease: an intervention mapping for adaptation approach.Frontiers in public health · 2026Article
- Early Intervention as a Way of Reducing Neurocognitive Delay in Pediatric Sickle Cell Patients.Cureus · 2025Review
- "I was very scared when I found out my son had sickle cell": Caregiver knowledge and attitudes toward early intervention for young children with sickle cell disease: Implications for policy and practice from a multi-site study.Pediatric blood & cancer · 2024Article
- Article
- Awareness, access, and communication: provider perspectives on early intervention services for children with sickle cell disease.Frontiers in pediatrics · 2024Article
- Molecular and environmental contributors to neurological complications in sickle cell disease.Experimental biology and medicine (Maywood, N.J.) · 2023Review
- Commentary on the ASH 2020 guidelines on cognitive screening and intervention in sickle cell disease.Blood advances · 2023Article
- Sickle cell disease and social determinants of health: A scoping review.Pediatric blood & cancer · 2023Article
- Predictors of Cognitive Performance Among Infants Treated for Brain Tumors: Findings From a Multisite, Prospective, Longitudinal Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021Article
- Socioeconomic status dependent medical complexities in children with sickle cell disease in Saudi Arabia.Saudi journal of biological sciences · 2020Article
- Stress and the Home Environment in Caregivers of Children with Sickle Cell.Journal of pediatric psychology · 2020Article
- Social-environmental factors and cognitive and behavioral functioning in pediatric sickle cell disease.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2020Article
- Responsive Parenting Behaviors and Cognitive Function in Children With Sickle Cell Disease.Journal of pediatric psychology · 2019Article
- Community Health Workers as Support for Sickle Cell Care.American journal of preventive medicine · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundYoung children with sickle cell disease (SCD) are at risk for cognitive delay. In addition to biologic risk factors associated with SCD, environmental factors contribute to cognitive dysfunction within this cohort.
methodsWe completed a single-arm, prospective cohort study. Children with SCD between the ages of 3 and 36 months and their caregivers were followed between October 2010 and December 2013. The aim was to describe the role of a home visitation model, the home environment, and socioeconomic status in the development of young children with SCD. Primary outcome measures were the Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III) and the Home Observation for Measurement of the Environment (HOME). We hypothesized that the home visitation model, Parents as Teachers
resultsThirty-five participants had at least two PAT visits and BSID-III assessments. Mean scores within all five subtests of the BSID-III improved between enrollment and exit, with significant changes within cognitive (P = 0.016) and expressive language (EL) domains (P = 0.002). Multivariate modeling found the HOME score associated with the exit results of the cognitive domain.
conclusionWe report longitudinal results of the first home visitation program within the early childhood SCD population and show significant improvement in cognitive and EL development. Additionally, home environment was a significant predictor of cognitive development. Randomized controlled trials to test the impact of interventions targeting the home environment are warranted for this vulnerable population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.