Evidence map›Paper›PMID 27509844›Full record

ArticleJournal of viral hepatitis2016

A matched comparison study of hepatitis C treatment outcomes in the prison and community setting, and an analysis of the impact of prison release or transfer during therapy.

E J Aspinall, W Mitchell, J Schofield, A Cairns, S Lamond, P Bramley, S E Peters, H Valerio, J Tomnay, D J Goldberg and 7 more

Open access · greenAbstract readComparative Study
In one paragraph

Article in Journal of viral hepatitis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 11 institutions in 2 countries.

E J AspinallSchool of Health and Life Sciences, Glasgow Caledonian University, Glasgow, UK.
W MitchellNHS Forth Valley Viral Hepatitis Service, Stirling, UK.
J SchofieldPublic Health Protection Unit, NHS Greater Glasgow and Clyde, Glasgow, UK.
A CairnsWestern General Hospital, Edinburgh, UK.
S LamondWestern General Hospital, Edinburgh, UK.
P BramleyNHS Forth Valley Viral Hepatitis Service, Stirling, UK.
S E PetersGartnavel General Hospital, Glasgow, UK.
H ValerioSchool of Health and Life Sciences, Glasgow Caledonian University, Glasgow, UK.
J TomnayCrosshouse Hospital, Kilmarnock, UK.
D J GoldbergSchool of Health and Life Sciences, Glasgow Caledonian University, Glasgow, UK.
P R MillsGartnavel General Hospital, Glasgow, UK.
S T BarclayWalton Liver Clinic, Glasgow Royal Infirmary, NHS Greater Glasgow and Clyde, Glasgow, UK.
A FraserAberdeen Royal Infirmary, NHS Grampian, Aberdeen, UK.
J F DillonNinewells Hospital and Medical School, NHS Tayside, Dundee, UK.
N K MartinDivision of Global Public Health, University of California San Diego, San Diego, CA, USA.
M HickmanSchool of Social and Community Medicine, University of Bristol, Bristol, UK.
S J HutchinsonSchool of Health and Life Sciences, Glasgow Caledonian University, Glasgow, UK.
Gartnavel General Hospital · GBGlasgow Caledonian University · GBHealth Protection Scotland · GBNHS Forth Valley · GBNHS Greater Glasgow and Clyde · GBWestern General Hospital · GBAberdeen Royal Infirmary · GBNHS Tayside · GBUniversity Hospital Crosshouse · GBUniversity of Bristol · GBUniversity of San Diego · US

Funding

VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUSAN JANET LITTLE · 1994 to 2026
$78.4M
Modeling Structural HIV Determinants in Substance Users and related populationsR01DA037773 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MARTIN, NATASHA, STRATHDEE, STEFFANIE A. · 2015 to 2017
$1.4M
Department of Health 12/136/105Department of Health PDF-2011-04-049Department of Health RP-DG-0610-10055Medical Research Council MR/K023233/1NIAID NIH HHS P30 AI036214NIDA NIH HHS R01 DA037773
6 · The paper itself

Abstract

Prisoners are a priority group for hepatitis C (HCV) treatment. Although treatment durations will become shorter using directly acting antivirals (DAAs), nearly half of prison sentences in Scotland are too short to allow completion of DAA therapy prior to release. The purpose of this study was to compare treatment outcomes between prison- and community-based patients and to examine the impact of prison release or transfer during therapy. A national database was used to compare treatment outcomes between prison treatment initiates and a matched community sample. Additional data were collected to investigate the impact of release or transfer on treatment outcomes. Treatment-naïve patients infected with genotype 1/2/3/4 and treated between 2009 and 2012 were eligible for inclusion. 291 prison initiates were matched with 1137 community initiates: SVRs were 61% (95% CI 55%-66%) and 63% (95% CI 60%-66%), respectively. Odds of achieving a SVR were not significantly associated with prisoner status (P=.33). SVRs were 74% (95% CI 65%-81%), 59% (95% CI 42%-75%) and 45% (95% CI 29%-62%) among those not released or transferred, transferred during treatment, or released during treatment, respectively. Odds of achieving a SVR were significantly associated with release (P<.01), but not transfer (P=.18). Prison-based HCV treatment achieves similar outcomes to community-based treatment, with those not released or transferred during treatment doing particularly well. Transfer or release during therapy should be avoided whenever possible, using anticipatory planning and medical holds where appropriate.

Indexed as

Sustained Virologic ResponseAdultAgedAntiviral AgentsFemaleHepatitis C, ChronicHumansMaleMiddle AgedPrisonsResidence CharacteristicsScotlandTreatment OutcomeYoung AdultAntiviral Agentshepatitis Cprisontreatment

Identifiers

PMID27509844
PMCPMC5558600
OpenAlexW2516279339

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.