Evidence map›Paper›PMID 27509543›Full record

ArticleRadiology2017

Application of Modified Spin-Echo-based Sequences for Hepatic MR Elastography: Evaluation, Comparison with the Conventional Gradient-Echo Sequence, and Preliminary Clinical Experience.

Yogesh K Mariappan, Bogdan Dzyubak, Kevin J Glaser, Sudhakar K Venkatesh, Claude B Sirlin, Jonathan Hooker, Kiaran P McGee, Richard L Ehman

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Real-World Assessment of Liver Corrected T1 and Magnetic Resonance Elastography in Predicting Liver Disease Progression.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Advances in Magnetic Resonance Elastography of Liver.Magnetic resonance imaging clinics of North America · 2020
    Review
  15. Review
  16. Article
  17. Article
  18. Diagnosis and Management of Genetic Iron Overload Disorders.Journal of general internal medicine · 2018
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yogesh K MariappanFrom the Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (Y.K.M., B.D., K.J.G., S.K.V., K.P.M., R.L.E.); and Department of Radiology, University of California, San Diego, Calif (C.B.S., J.H.).
Bogdan DzyubakFrom the Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (Y.K.M., B.D., K.J.G., S.K.V., K.P.M., R.L.E.); and Department of Radiology, University of California, San Diego, Calif (C.B.S., J.H.).
Kevin J GlaserFrom the Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (Y.K.M., B.D., K.J.G., S.K.V., K.P.M., R.L.E.); and Department of Radiology, University of California, San Diego, Calif (C.B.S., J.H.).
Sudhakar K VenkateshFrom the Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (Y.K.M., B.D., K.J.G., S.K.V., K.P.M., R.L.E.); and Department of Radiology, University of California, San Diego, Calif (C.B.S., J.H.).
Claude B SirlinFrom the Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (Y.K.M., B.D., K.J.G., S.K.V., K.P.M., R.L.E.); and Department of Radiology, University of California, San Diego, Calif (C.B.S., J.H.).
Jonathan HookerFrom the Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (Y.K.M., B.D., K.J.G., S.K.V., K.P.M., R.L.E.); and Department of Radiology, University of California, San Diego, Calif (C.B.S., J.H.).
Kiaran P McGeeFrom the Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (Y.K.M., B.D., K.J.G., S.K.V., K.P.M., R.L.E.); and Department of Radiology, University of California, San Diego, Calif (C.B.S., J.H.).
Richard L EhmanFrom the Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (Y.K.M., B.D., K.J.G., S.K.V., K.P.M., R.L.E.); and Department of Radiology, University of California, San Diego, Calif (C.B.S., J.H.).
Mayo Clinic · USUniversity of California, San Diego · US

Funding

Technical Validation of MRI Biomarkers of Liver FatR01DK088925 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B., SIRLIN, CLAUDE B · 2010 to 2021
$7.1M
Magnetic Resonance ElastographyR37EB001981 · NIBIB · MAYO CLINIC ROCHESTER · PI EHMAN, RICHARD L. · 2016 to 2025
$4.0M
Magnetic Resonance ElastographyR01EB001981 · NIBIB · MAYO CLINIC ROCHESTER · PI EHMAN, RICHARD L. · 2003 to 2013
$3.1M
Regional Assessment of the Lung Using Magnetic Resonance Elastography (MRE)R01EB007593 · NIBIB · MAYO CLINIC ROCHESTER · PI MCGEE, KIARAN PATRICK · 2009 to 2010
$696k
NIBIB NIH HHS R01 EB001981NIBIB NIH HHS R01 EB007593NIBIB NIH HHS R37 EB001981NIDDK NIH HHS R01 DK088925
6 · The paper itself

Abstract

Purpose To (a) evaluate modified spin-echo (SE) magnetic resonance (MR) elastographic sequences for acquiring MR images with improved signal-to-noise ratio (SNR) in patients in whom the standard gradient-echo (GRE) MR elastographic sequence yields low hepatic signal intensity and (b) compare the stiffness values obtained with these sequences with those obtained with the conventional GRE sequence. Materials and Methods This HIPAA-compliant retrospective study was approved by the institutional review board; the requirement to obtain informed consent was waived. Data obtained with modified SE and SE echo-planar imaging (EPI) MR elastographic pulse sequences with short echo times were compared with those obtained with the conventional GRE MR elastographic sequence in two patient cohorts, one that exhibited adequate liver signal intensity and one that exhibited low liver signal intensity. Shear stiffness values obtained with the three sequences in 130 patients with successful GRE-based examinations were retrospectively tested for statistical equivalence by using a 5% margin. In 47 patients in whom GRE examinations were considered to have failed because of low SNR, the SNR and confidence level with the SE-based sequences were compared with those with the GRE sequence. Results The results of this study helped confirm the equivalence of SE MR elastography and SE-EPI MR elastography to GRE MR elastography (P = .0212 and P = .0001, respectively). The SE and SE-EPI MR elastographic sequences provided substantially improved SNR and stiffness inversion confidence level in 47 patients in whom GRE MR elastography had failed. Conclusion Modified SE-based MR elastographic sequences provide higher SNR MR elastographic data and reliable stiffness measurements; thus, they enable quantification of stiffness in patients in whom the conventional GRE MR elastographic sequence failed owing to low signal intensity. The equivalence of the three sequences indicates that the current diagnostic thresholds are applicable to SE MR elastographic sequences for assessing liver fibrosis.

Indexed as

AdultAgedAged, 80 and overEcho-Planar ImagingElasticity Imaging TechniquesFemaleHumansLiver DiseasesMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesSignal-To-Noise Ratio

Identifiers

PMID27509543
PMCPMC5283871
OpenAlexW2499513341

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.