Evidence map›Paper›PMID 27509521›Full record

SynthesisNutrients2016

Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Ruixue Huang, Ke Wang, Jianan Hu

4 registry-linked trialsOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 226 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
226citing papers in PubMed, 20 pooled it
19.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03877393 naunknown statusnot on this mapstarted 2019, after this paper: background citation

A 12-week, Randomized, Double-blind, and Placebo-controlled Study Evaluating the Effect of Probiotic Supplementation on the Mental Status, Inflammation, And Intestinal Barrier in Major Depressive Disorder Patients Using Gluten-free or Gluten-containing Diet

TypeinterventionalSponsorMedical University of LublinRan2019 to 2021Enrolled120ConditionsDepressive Disorder, Major, DepressionArmsProbiotic supplementation + gluten-free diet, Placebo supplementation + gluten-free diet, Probiotic supplementation + gluten-containing diet, Placebo supplementation + gluten-containing diet
NCT05603403 phase4completednot on this mapstarted 2022, after this paper: background citation

Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial Placebo-Controlled Clinical Trial To Evaluate The Efficacy And Safety Of Probiatop In The Treatment Of Digestive Symptoms

TypeinterventionalSponsorAzidus BrasilRan2022 to 2023Enrolled150ConditionsSigns and Symptoms, DigestiveArmsProbiatop, Placebo
NCT05762887 nacompletednot on this mapstarted 2023, after this paper: background citation

Clinical Evaluation of the Antidepressant Effect of the Use of Probiotics in Bipolar Disorder and Possible Mediating Effects of Systemic and Intestinal Inflammatory Markers in the Microbiota

TypeinterventionalSponsorUniversity of Sao PauloRan2023 to 2025Enrolled141ConditionsBipolar DisorderArmsProbiotic Group, Placebo Group
NCT06905223 narecruitingnot on this mapstarted 2025, after this paper: background citation

A Pilot Study on the Efficacy of a Synbiotic Formula (MQU10) in Improving Mood and Well-being in Adults With Mild to Moderate Depressive Symptoms

TypeinterventionalSponsorGenieBiome LimitedRan2025 to 2027Enrolled30ConditionsDepressive Symptoms Mild to Moderate in SeverityArmsMQU10
3 · Its place in the literature

Who cites it

226 citing papers in PubMed, 20 syntheses or guidelines pooled it, 500 citations in OpenAlex.

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  12. Frontiers in behavioral neuroscience · 2021
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166 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ruixue HuangDepartment of Occupational and Environmental health, Xiangya school of Public Health, Central South University, Changsha 410078, Hunan, China. huangruixue@csu.edu.cn.
Ke WangDepartment of Occupational and Environmental health, Xiangya school of Public Health, Central South University, Changsha 410078, Hunan, China. wangke2138@126.com.
Jianan HuDepartment of Occupational and Environmental health, Xiangya school of Public Health, Central South University, Changsha 410078, Hunan, China. huja_xy@126.com.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has been reported that gut probiotics play a major role in the bidirectional communication between the gut and the brain. Probiotics may be essential to people with depression, which remains a global health challenge, as depression is a metabolic brain disorder. However, the efficacy of probiotics for depression is controversial. This study aimed to systematically review the existing evidence on the effect of probiotics-based interventions on depression. Randomized, controlled trials, identified through screening multiple databases and grey literature, were included in the meta-analysis. The meta-analysis was performed using Review Manager 5.3 software using a fixed-effects model. The meta-analysis showed that probiotics significantly decreased the depression scale score (MD (depressive disorder) = -0.30, 95% CI (-0.51--0.09), p = 0.005) in the subjects. Probiotics had an effect on both the healthy population (MD = -0.25, 95% CI (-0.47--0.03), p = 0.03) and patients with major depressive disorder (MDD) (MD = -0.73, 95% CI (-1.37--0.09), p = 0.03). Probiotics had an effect on the population aged under 60 (MD = -0.43, 95% CI (-0.72--0.13), p = 0.005), while it had no effect on people aged over 65 (MD = -0.18, 95% CI (-0.47-0.11), p = 0.22). This is the first systematic review and meta-analysis with the goal of determining the effect of probiotics on depression. We found that probiotics were associated with a significant reduction in depression, underscoring the need for additional research on this potential preventive strategy for depression.

Indexed as

Evidence-Based MedicineGlobal HealthAdultAge FactorsAnimalsDepressionDysbiosisHumansMajor Depressive DisorderProbioticsRandomized Controlled Trials as TopicRiskdepressionmeta-analysisprobioticsrandomized controlled trial

Identifiers

PMID27509521
PMCPMC4997396
OpenAlexW2478760258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.