Evidence map›Paper›PMID 27509488›Full record

ArticleAmerican journal of respiratory cell and molecular biology2016

Diversity of Human and Macaque Airway Immune Cells at Baseline and during Tuberculosis Infection.

Richard F Silver, Amy J Myers, Jessica Jarvela, JoAnne Flynn, Tara Rutledge, Tracey Bonfield, Philana Ling Lin

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Extracellular Vesicle ASC: A Novel Mediator for Lung-Brain Axis in Preterm Brain Injury.American journal of respiratory cell and molecular biology · 2024
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. The End of the Binary Era: Revisiting the Spectrum of Tuberculosis.Journal of immunology (Baltimore, Md. : 1950) · 2018
    Review
  12. Review
  13. Review
  14. Toll-like receptor 2Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2017
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Richard F Silver1 Division of Pulmonary, Critical Care and Sleep Medicine.
Amy J Myers4 Departments of Microbiology and Molecular Genetics and.
Jessica Jarvela1 Division of Pulmonary, Critical Care and Sleep Medicine.
JoAnne Flynn4 Departments of Microbiology and Molecular Genetics and.
Tara Rutledge5 Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Tracey Bonfield6 Pediatric Pulmonology, Allergy and Immunology, Case Western Reserve University School of Medicine, Cleveland, Ohio; and.
Philana Ling Lin5 Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.ORCID 0000-0001-5169-3714
University of Pittsburgh · USSleepMed · USUniversity Hospitals Cleveland Medical Center · USUniversity School · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024989 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$53.7M
HIV-TB Co-infection: Tracking TB emergence after asymptomatic (latent) infectionR01AI111871 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LIN, PHILANA LING · 2014 to 2018
$3.3M
Proteogenomics of dysregulated protein interaction networks in MTB infectionR01HL106798 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI BOOM, W. HENRY, CHANCE, MARK R · 2010 to 2013
$2.8M
Defining how the spectrum of latency affects reactivation of TBR01HL106804 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FLYNN, JOANNE L., KIRSCHNER, DENISE E · 2010 to 2013
$2.6M
Expression signatures of TB-specific memory responses within the human lungR01HL111523 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI SILVER, RICHARD F · 2013 to 2018
$2.6M
Data Coordinating Center for Systems Biology Approach to the Mechanisms of TBR01HL106800 · NHLBI · UNIVERSITY OF WASHINGTON · PI BENNETT, SIIRI, KERR, KATHLEEN F. · 2010 to 2013
$2.3M
NCRR NIH HHS UL1 RR024989NHLBI NIH HHS R01 HL106798NHLBI NIH HHS R01 HL106800NHLBI NIH HHS R01 HL106804NHLBI NIH HHS R01 HL111523NIAID NIH HHS R01 AI111871
6 · The paper itself

Abstract

Immune cells of the distal airways serve as "first responders" of host immunity to the airborne pathogen Mycobacterium tuberculosis (Mtb). Mtb infection of cynomolgus macaques recapitulates the range of human outcomes from clinically silent latent tuberculosis infection (LTBI) to active tuberculosis of various degrees of severity. To further advance the application of this model to human studies, we compared profiles of bronchoalveolar lavage (BAL) cells of humans and cynomolgus macaques before and after Mtb infection. A simple gating strategy effectively defined BAL T-cell and phagocyte populations in both species. BAL from Mtb-naive humans and macaques showed similar differential cell counts. BAL T cells of macaques were composed of fewer CD4

Indexed as

AdolescentAdultAnimalsBiomarkersBronchoalveolar Lavage FluidHumansLatent TuberculosisLeukocyte CountLeukocytesLungLymphocyte SubsetsMacaca fascicularisMiddle AgedMycobacterium tuberculosisPhagocytesPhenotypeBiomarkersalveolar macrophagesbronchoalveolar lavagehuman subjectsmacaquestuberculosis

Identifiers

PMID27509488
PMCPMC5248955
OpenAlexW2497621485

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.