Evidence map›Paper›PMID 27509359›Full record

ArticleAmerican journal of respiratory and critical care medicine2017

Lung Function in African Infants in the Drakenstein Child Health Study. Impact of Lower Respiratory Tract Illness.

Diane M Gray, Lidija Turkovic, Lauren Willemse, Ane Visagie, Aneesa Vanker, Dan J Stein, Peter D Sly, Graham L Hall, Heather J Zar

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of respiratory and critical care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 2 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 111 citations in OpenAlex.

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  14. The impact of child and adolescent health on adult respiratory health: the evidence, gaps and priorities.European respiratory review : an official journal of the European Respiratory Society · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Diane M Gray1 Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and MRC Unit on Child and Adolescent Health, and.ORCID 0000-0002-7712-6774
Lidija Turkovic2 Telethon Kids Institute and Centre for Child Health, University of Western Australia, Perth, Australia.
Lauren Willemse1 Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and MRC Unit on Child and Adolescent Health, and.
Ane Visagie1 Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and MRC Unit on Child and Adolescent Health, and.
Aneesa Vanker1 Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and MRC Unit on Child and Adolescent Health, and.
Dan J Stein3 Department of Psychiatry, University of Cape Town, Cape Town, South Africa.
Peter D Sly4 Children's Lung, Environment and Asthma Research, Child Health Research Centre, University of Queensland and Queensland Children's Medical Research Institute, Brisbane, Australia; and.
Graham L Hall2 Telethon Kids Institute and Centre for Child Health, University of Western Australia, Perth, Australia.
Heather J Zar1 Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and MRC Unit on Child and Adolescent Health, and.
Red Cross War Memorial Children's Hospital · ZAThe Kids Research Institute Australia · AUChildren's Medical Research Institute · AUUniversity of Cape Town · ZA

Funding

Wellcome Trust 098479/Z/12/ZWellcome Trust 204755/Z/16/Z
6 · The paper itself

Abstract

rationaleLower respiratory tract illness is a major cause of childhood morbidity and mortality. It is unknown whether infants are predisposed to illness because of impaired lung function or whether respiratory illness reduces lung function.

objectivesTo investigate the impact of early life exposures, including lower respiratory tract illness, on lung function during infancy.

methodsInfants enrolled in the Drakenstein child health study had lung function at 6 weeks and 1 year. Testing during quiet natural sleep included tidal breathing, exhaled nitric oxide, and multiple breath washout measures. Risk factors for impaired lung health were collected longitudinally. Lower respiratory tract illness surveillance was performed and any episode investigated. MEASUREMENTS AND MAIN

resultsLung function was tested in 648 children at 1 year. One hundred and fifty (29%) infants had a lower respiratory tract illness during the first year of life. Lower respiratory tract illness was independently associated with increased respiratory rate (4%; 95% confidence interval [CI], 1.01-1.08; P = 0.02). Repeat episodes further increased respiratory rate (3%; 95% CI, 1.01-1.05; P = 0.004), decreased tidal volume (-1.7 ml; 95% CI, -3.3 to -0.2; P = 0.03), and increased the lung clearance index (0.13 turnovers; 95% CI, 0.04-0.22; P = 0.006) compared with infants without illness. Tobacco smoke exposure, lung function at 6 weeks, infant growth, and prematurity were other independent predictors of lung function at 1 year.

conclusionsEarly life lower respiratory tract illness impairs lung function at 1 year, independent of baseline lung function. Preventing early life lower respiratory tract illness is important to optimize lung function and promote respiratory health in childhood.

Indexed as

FemaleHealth StatusHumansInfantLungMaleRespiratory Function TestsRespiratory RateRespiratory Tract DiseasesSocioeconomic FactorsSouth AfricaTidal VolumeTobacco Smoke PollutionTobacco Smoke PollutionepidemiologyinfantLRTIlung functionlung growth and development

Identifiers

PMID27509359
PMCPMC5394784
OpenAlexW2493788686

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.