ArticlePloS one2016
The Characteristics and Prognostic Effect of E-Cadherin Expression in Colorectal Signet Ring Cell Carcinoma.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Systematic review of risk factors, prognosis, and management of colorectal signet-ring cell carcinoma.World journal of gastrointestinal oncology · 2024Article
- Prognostic and predictive value of tumor deposits in advanced signet ring cell colorectal cancer: SEER database analysis and multicenter validation.World journal of surgical oncology · 2024Article
- E-Cadherin Is Expressed in Epithelial Cells of the Choroid Plexus in Human and Mouse Brains.Current issues in molecular biology · 2023Article
- Intestinal type adenocarcinoma of the endometrium with signet ring cells, a rare aggressive variant.Gynecologic oncology reports · 2022Article
- An Extremely Rare Case of Rectal Signet Ring Cell Carcinoma.Gastroenterology research · 2022Article
- Article
- Prognostic Outcomes of Signet Ring Cell Carcinoma of the Breast.The Journal of surgical research · 2021Article
- Prognostic Nomogram for Liver Metastatic Colon Cancer Based on Histological Type, Tumor Differentiation, and Tumor Deposit: A TRIPOD Compliant Large-Scale Survival Study.Frontiers in oncology · 2021Article
- Clinicopathological and Molecular Characteristics of Colorectal Signet Ring Cell Carcinoma: A Review.Pathology oncology research : POR · 2021Review
- Identification of Subtypes and a Prognostic Gene Signature in Colon Cancer Using Cell Differentiation Trajectories.Frontiers in cell and developmental biology · 2021Article
- Clinical Significance of CLDN18.2 Expression in Metastatic Diffuse-Type Gastric Cancer.Journal of gastric cancer · 2020Article
- Multiple polypoid colonic metastases from rectal adenocarcinoma with signet ring cells features: a case report.BMC gastroenterology · 2020Article
- Nomogram to predict the risk and survival of synchronous bone metastasis in colorectal cancer: a population-based real-world analysis.International journal of colorectal disease · 2020Article
- Enhanced glutamine utilization mediated by SLC1A5 and GPT2 is an essential metabolic feature of colorectal signet ring cell carcinoma with therapeutic potential.Annals of translational medicine · 2020Article
- E-cadherin Beyond Structure: A Signaling Hub in Colon Homeostasis and Disease.International journal of molecular sciences · 2019Review
- E-cadherin: A potential biomarker of colorectal cancer prognosis.Oncology letters · 2017Article
- Characteristics and prognostic factors of colorectal mucinous adenocarcinoma with signet ring cells.Cancer management and research · 2017Article
- Early-Onset Signet-Ring Cell Adenocarcinoma of the Colon: A Case Report and Review of the Literature.Case reports in oncological medicine · 2017Article
- Younger Age Is Associated with Poorer Survival in Patients with Signet-Ring Cell Carcinoma of the Colon without Distant Metastasis.Gastroenterology research and practice · 2016Article
- E-cadherin and Snail Immunoexpression in Colorectal Adenocarcinomas.Current health sciences journalArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSignet ring cell carcinoma (SRCC) is rare. The aim of this study is to understand the clinicopathological features and identify the possible prognostic factors in colorectal SRCC.
methodsPatients with SRCC who underwent primary lesion resection at Fudan University Shanghai Cancer Center from September 2008 to July 2014 were retrospectively analyzed. Patient's gender, age, tumor location, depth of invasion, lymph node metastasis, synchronous distant metastasis, perineural invasion, lymphovascular invasion, and E-cadherin expression were studied with prognosis, and the correlation between E-cadherin expression and clinicopathological features were analyzed. All clinicopathological and molecular factors were put into multivariate analysis using Cox proportional hazards model for detecting independent prognostic factors.
results59 patients accounting for 0.89% of total colorectal cancer patients met the criteria and were enrolled in the study. The median survival time is 28.9 months, and the 3-year survival rate is 62.7%. SRCC were seen more common in young male patients. Advanced stage was more common in SRCC, 58 (98.3%) patients had T3/T4 lesions, 52 (88.1%) patients had lymph node metastasis, and 14 (23.7%) patients had distant metastasis. Distant metastases were seen more common in peritoneal cavity. Distant metastasis (HR = 4.194, 95% CI: 1.297-13.567), lymphovascular invasion (HR = 2.888, 95% CI: 1.115-7.483), and E-cadherin expression (HR = 0.272, 95% CI: 0.096-0.768) were independent predictors for survival.
conclusionsSRCC is a rare subtype of colorectal cancer with poor prognosis. Distant metastasis, lymphovascular invasion, and E-cadherin expression can predict prognosis of colorectal SRCCs independently. More precise therapy and more close surveillance are needed for these patients.
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