Evidence map›Paper›PMID 27509031›Full record

ArticleJournal of cellular biochemistry2017

Characterization of Laminin Binding Integrin Internalization in Prostate Cancer Cells.

Lipsa Das, Todd A Anderson, Jaime M C Gard, Isis C Sroka, Stephanie R Strautman, Raymond B Nagle, Colm Morrissey, Beatrice S Knudsen, Anne E Cress

Open access · greenAbstract read
In one paragraph

Article in Journal of cellular biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  6. Review
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  8. Targeted Drug Delivery via the Use of ECM-Mimetic Materials.Frontiers in bioengineering and biotechnology · 2020
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Precision engineering of targeted nanocarriers.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2018
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Lipsa DasCancer Biology Program, University of Arizona, Tucson, Arizona 85724.
Todd A AndersonThe University of Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724.
Jaime M C GardThe University of Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724.
Isis C SrokaDepartment of Pharmacology, University of Arizona, Tucson, Arizona 85724.
Stephanie R StrautmanDepartment of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona 85724.
Raymond B NagleThe University of Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724.
Colm MorrisseyUniversity of Washington, Seattle, Washington 98195.
Beatrice S KnudsenCedars Sinai Medical Center, Los Angeles, California 90048.
Anne E CressThe University of Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724.
University of Arizona · USUniversity of Arizona Cancer CenterCedars-Sinai Medical Center · USUniversity of Washington · US

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Teri L Bankhead · 1985 to 2026
$110.2M
Integrative Cancer Scholars Training GrantT32CA009213 · NCI · UNIVERSITY OF ARIZONA · PI CAREW, JENNIFER S, CURIEL-LEWANDROWSKI, CLARA · 1985 to 2024
$8.6M
Human Prostate Cancer Metastasis and Laminin Binding IntegrinsR01CA159406 · NCI · UNIVERSITY OF ARIZONA · PI CRESS, ANNE E · 2011 to 2015
$1.5M
NCI NIH HHS P30 CA023074NCI NIH HHS R01 CA159406NCI NIH HHS T32 CA009213
6 · The paper itself

Abstract

Laminin binding integrins α6 (CD49f) and α3 (CD49c) are persistently but differentially expressed in prostate cancer (PCa). Integrin internalization is an important determinant of their cell surface expression and function. Using flow cytometry, and first order kinetic modeling, we quantitated the intrinsic internalization rates of integrin subunits in a single cycle of internalization. In PCa cell line DU145, α6 integrin internalized with a rate constant (k

Indexed as

Cell Line, TumorCell MovementEndosomesGene SilencingHumansIntegrin alpha3Integrin alpha6MaleProstatic NeoplasmsProtein TransportIntegrin alpha3Integrin alpha6ITGA3 protein, humanITGA6 protein, humanENDOSOMESINTEGRININTERNALIZATION KINETICSLAMININPROSTATE CANCER

Identifiers

PMID27509031
PMCPMC5553695
OpenAlexW2515529843

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.