Evidence map›Paper›PMID 27508867›Full record

ArticleCell metabolism2016

When Hexokinase Gets that NAG-ing Feeling….

David O'Sullivan, Beth Kelly, Erika L Pearce

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Biochemistry of proinflammatory macrophage activation.Cellular and molecular life sciences : CMLS · 2018
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

David O'SullivanDepartment of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany. Electronic address: osullivan@ie-freiburg.mpg.de.
Beth KellyDepartment of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Erika L PearceDepartment of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany. Electronic address: pearce@ie-freiburg.mpg.de.
Max Planck Institute of Immunobiology and Epigenetics · DE

Funding

Metabolic Regulation of CD8 T Cell Memory DevelopmentR01AI091965 · NIAID · WASHINGTON UNIVERSITY · PI PEARCE, ERIKA L · 2011 to 2015
$1.9M
TUMOR-IMPOSED GLUCOSE RESTRICTIONS ON T CELLS DAMPEN IMMUNITYR01CA181125 · NCI · WASHINGTON UNIVERSITY · PI PEARCE, ERIKA L · 2014 to 2017
$989k
NCI NIH HHS R01 CA181125NIAID NIH HHS R01 AI091965
6 · The paper itself

Abstract

Immune cell recognition of bacterial products usually occurs via specific pattern recognition receptors, but new research recently published in Cell by Wolf et al. (2016) demonstrates that the glycolytic enzyme hexokinase can act as an innate immune sensor by binding to bacterial derived N-acetylglucosamine (NAG).

Indexed as

AcetylglucosamineHexokinaseGlycolysisAcetylglucosamineHexokinase

Identifiers

PMID27508867
PMCPMC5572107
OpenAlexW2490186997

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.