ArticleBiophysical journal2016
Mechanical Regulation of Three-Dimensional Epithelial Fold Pattern Formation in the Mouse Oviduct.
Article in Biophysical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Successful oocyte transport through the oviduct does not depend on the longitudinal alignment of oviduct epithelial folds.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Tissue-scale in vitro epithelial wrinkling and wrinkle-to-fold transition.Nature communications · 2024Article
- Article
- Effective mechanical potential of cell-cell interaction in tissues harboring cavity and in cell sheet toward morphogenesis.Frontiers in cell and developmental biology · 2024Article
- Patterning and folding of intestinal villi by active mesenchymal dewetting.bioRxiv : the preprint server for biology · 2023Article
- Transcriptome identification of genes associated with uterus-vagina junction epithelial folds formation in chicken hens.Poultry science · 2023Article
- Developmentally interdependent stretcher-compressor relationship between the embryonic brain and the surrounding scalp in the preosteogenic head.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- Differential Cellular Stiffness Contributes to Tissue Elongation on an Expanding Surface.Frontiers in cell and developmental biology · 2022Article
- Computational analyses decipher the primordial folding coding the 3D structure of the beetle horn.Scientific reports · 2021Article
- Epithelial tissue folding pattern in confined geometry.Biomechanics and modeling in mechanobiology · 2020Article
- Biophysical research in Okazaki, Japan.Biophysical reviews · 2020Review
- Smooth muscle differentiation shapes domain branches during mouse lung development.Development (Cambridge, England) · 2019Article
- Smooth muscle contractility causes the gut to grow anisotropically.Journal of the Royal Society, Interface · 2019Article
- Biophysics in oviduct: Planar cell polarity, cilia, epithelial fold and tube morphogenesis, egg dynamics.Biophysics and physicobiology · 2019Review
- Smooth muscle: a stiff sculptor of epithelial shapes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Chick midgut morphogenesis.The International journal of developmental biology · 2018Review
- Geometric constraints alter cell arrangements within curved epithelial tissues.Molecular biology of the cell · 2017Article
- Generating tissue topology through remodeling of cell-cell adhesions.Experimental cell research · 2017Review
- BMP signaling controls buckling forces to modulate looping morphogenesis of the gut.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epithelia exhibit various three-dimensional morphologies linked to organ function in animals. However, the mechanisms of three-dimensional morphogenesis remain elusive. The luminal epithelium of the mouse oviduct forms well-aligned straight folds along the longitudinal direction of the tubes. Disruption of the Celsr1 gene, a planar cell polarity-related gene, causes ectopically branched folds. Here, we evaluated the mechanical contributions of the epithelium to the fold pattern formation. In the mutant oviduct, the epithelium was more intricate along the longitudinal direction than in the wild-type, suggesting a higher ratio of the longitudinal length of the epithelial layer to that of the surrounding smooth muscle (SM) layer (L-Epi/SM ratio). Our mathematical modeling and computational simulations suggested that the L-Epi/SM ratio could explain the differences in fold branching between the two genotypes. Longitudinal epithelial tensions were increased in well-aligned folds compared with those in disorganized folds both in the simulations and in experimental estimations. Artificially increasing the epithelial tensions suppressed the branching in simulations, suggesting that the epithelial tensions can regulate fold patterning. The epithelial tensions could be explained by the combination of line tensions along the epithelial cell-cell boundaries with the polarized cell arrays observed in vivo. These results suggest that the fold pattern is associated with the polarized cell array through the longitudinal epithelial tension. Further simulations indicated that the L-Epi/SM ratio could contribute to fold pattern diversity, suggesting that the L-Epi/SM ratio is a critical parameter in the fold patterning in tubular organs.
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