ArticleBiophysical journal2016
The Effect of Hematocrit on Platelet Adhesion: Experiments and Simulations.
Article in Biophysical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 75 citations in OpenAlex.
- Trial
- A stochastic, physiology-based digital twin model of hemostasis and oxygenation in trauma resuscitation.Research square · 2026Article
- Impact of anemia prior to catheter ablation for atrial fibrillation on clinical outcomes: a U.S. retrospective cohort analysis.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- Combined Effect of Hemoglobin Levels and Obesity on the Risk of Incident Venous Thromboembolism: The Tromsø Study.TH open : companion journal to thrombosis and haemostasis · 2026Article
- Correlation between the hemoglobin-to-hematocrit ratio and 3-month outcomes in patients with acute ischemic stroke: a secondary analysis based on a prospective cohort study.Frontiers in neurology · 2025Article
- Article
- Influence of Hematocrit Level and Integrin αCellular and molecular bioengineering · 2024Article
- Safety and efficacy of direct oral anticoagulants in stroke prevention in patients with atrial fibrillation complicated with anemia and/or thrombocytopenia: a retrospective cohort study.Thrombosis journal · 2023Article
- Relation between laxative use and risk of major bleeding in patients with atrial fibrillation and heart failure.Heart and vessels · 2023Article
- Biomechanical activation of blood platelets via adhesion to von Willebrand factor studied with mesoscopic simulations.Biomechanics and modeling in mechanobiology · 2023Article
- Traumatic hemorrhage and chain of survival.Scandinavian journal of trauma, resuscitation and emergency medicine · 2023Review
- A Multiscale Model for Shear-Mediated Platelet Adhesion Dynamics: Correlating In Silico with In Vitro Results.Annals of biomedical engineering · 2023Article
- The interaction of vortical flows with red cells in venous valve mimics.Biomicrofluidics · 2022Article
- Increased platelet thrombus formation under flow conditions in whole blood from polycythaemia vera patients.Blood transfusion = Trasfusione del sangue · 2022Article
- The Effects of Micro-vessel Curvature Induced Elongational Flows on Platelet Adhesion.Annals of biomedical engineering · 2021Article
- Effect of upstream priming on transient downstream platelet-substrate interactions.Colloids and surfaces. B, Biointerfaces · 2021Article
- Coagulation Abnormalities in Renal Pathology of Chronic Kidney Disease: The Interplay between Blood Cells and Soluble Factors.Biomolecules · 2021Article
- Influence of shear rate and surface chemistry on thrombus formation in micro-crevice.Journal of biomechanics · 2021Article
- Flow-induced segregation and dynamics of red blood cells in sickle cell disease.Physical review fluids · 2020Article
- Hematocrit and incidence of venous thromboembolism.Research and practice in thrombosis and haemostasis · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The volume fraction of red blood cells (RBCs) in a capillary affects the degree to which platelets are promoted to marginate to near a vessel wall and form blood clots. In this work we investigate the relationship between RBC hematocrit and platelet adhesion activity. We perform experiments flowing blood samples through a microfluidic channel coated with type 1 collagen and observe the rate at which platelets adhere to the wall. We compare these results with three-dimensional boundary integral simulations of a suspension of RBCs and platelets in a periodic channel where platelets can adhere to the wall. In both cases, we find that the rate of platelet adhesion varies greatly with the RBC hematocrit. We observe that the relative decrease in platelet activity as hematocrit falls shows a similar profile for simulation and experiment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.