ArticleRevista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
Impairment of fine motor dexterity in mild cognitive impairment and Alzheimer's disease dementia: association with activities of daily living.
Article in Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 5 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Motor performance and its association with Alzheimer's-related biomarkers: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- Function of the hand as a predictor of early diagnosis and progression of Alzheimer's dementia: A systematic review.Technology and health care : official journal of the European Society for Engineering and Medicine · 2024Pooled it
- Diagnostic accuracy of keystroke dynamics as digital biomarkers for fine motor decline in neuropsychiatric disorders: a systematic review and meta-analysis.Scientific reports · 2022Pooled it
- Neural Mechanisms of Motor Dysfunction in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review.Journal of Alzheimer's disease reports · 2022Pooled it
- Observational Evidence of the Association Between Handgrip Strength, Hand Dexterity, and Cognitive Performance in Community-Dwelling Older Adults: A Systematic Review.Journal of epidemiology · 2018Pooled it
- The Cog-Aging: a 15-year cohort study of cognition in Brazilian older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- A real-world feasibility study: at home longitudinal use of the Cumulus NeuLogiq® platform for electrophysiological and neurocognitive measures in patients with mild Alzheimer's Disease dementia.Frontiers in digital health · 2026Article
- Perceiving, interpreting and responding to changes in hand function among older adults with mild cognitive impairment: a common-sense model-informed qualitative study.Frontiers in psychiatry · 2026Article
- Age-related changes in hand function - it's not just about muscle strength.Frontiers in human neuroscience · 2026Review
- Article
- Hand dexterity and mobility independently predict cognition in older adults: a multi-domain regression analysis.Frontiers in aging neuroscience · 2025Article
- Correlation of muscle strength, information processing speed and cognitive function in the elderly with cognitive impairment--evidence from EEG.Frontiers in aging neuroscience · 2025Article
- The Relationship Between Reduced Hand Dexterity and Brain Structure Abnormality in Older Adults.Geriatrics (Basel, Switzerland) · 2024Article
- A multicenter study on the sex difference of dysfunctions among rehabilitation outpatients in China.Scientific reports · 2024Article
- A nonhuman primate model with Alzheimer's disease-like pathology induced by hippocampal overexpression of human tau.Alzheimer's research & therapy · 2024Article
- Classification of Mild Cognitive Impairment and Alzheimer's Disease Using Manual Motor Measures.Neuro-degenerative diseases · 2024Article
- Preliminary report: Reduced hand sensory and motor function in persons living with heart failure.PloS one · 2024Article
- Cognitive dysfunction in patients with childhood-onset systemic lupus erythematosus may impact treatment.Advances in rheumatology (London, England) · 2023Article
- Effects of home-based manual dexterity training on cognitive function among older adults: a randomized controlled trial.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2023Article
- Hand Dexterity Is Associated with the Ability to Resolve Perceptual and Cognitive Interference in Older Adults: Pilot Study.Geriatrics (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCognitive impairment is a hallmark of mild cognitive impairment (MCI) and Alzheimer's disease dementia (AD). Although the cognitive profile of these patients and its association with activities of daily living (ADLs) is well documented, few studies have assessed deficits in fine motor dexterity and their association with ADL performance. The objective of this research paper is to evaluate fine motor dexterity performance among MCI and AD patients and to investigate its association with different aspects of ADLs.
methodsWe assessed normal aging controls, patients with multiple- and single-domain amnestic MCI (aMCI), and patients with mild AD. Fine motor dexterity was measured with the Nine-Hole Peg Test and cognitive functioning by the Mattis Dementia Rating Scale. We analyzed the data using general linear models.
resultsPatients with AD or multiple-domain aMCI had slower motor responses when compared to controls. AD patients were slower than those with single-domain aMCI. We found associations between cognition and instrumental ADLs, and between fine motor dexterity and self-care ADLs.
conclusionWe observed progressive slowing of fine motor dexterity along the normal aging-MCI-AD spectrum, which was associated with autonomy in self-care ADLs.
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