ArticleCancer2016
White adipose tissue inflammation and cancer-specific survival in patients with squamous cell carcinoma of the oral tongue.
Article in Cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Mechanisms of obesity- and diabetes mellitus-related pancreatic carcinogenesis: a comprehensive and systematic review.Signal transduction and targeted therapy · 2023Pooled it
- Signals from the Adipose Microenvironment and the Obesity-Cancer Link-A Systematic Review.Cancer prevention research (Philadelphia, Pa.) · 2017Pooled it
- Mechanical interplay between adipose tissues and disease progression.Bioengineering & translational medicine · 2026Review
- Adipocytes enhance tongue cancer progression potentially via IL-6 and extracellular vesicles.Scientific reports · 2025Article
- The adipokines in oral cancer pathogenesis and its potential as a new therapeutic approach.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Prognostic Value of the Immunohistochemical Detection of Cellular Components of the Tumor Microenvironment in Oral Squamous Cell Carcinoma: A Systematic Review.Current issues in molecular biology · 2025Review
- Predicting lymph node recurrence in cT1-2N0 tongue squamous cell carcinoma: collaboration between artificial intelligence and pathologists.The journal of pathology. Clinical research · 2024Article
- Review
- Impact of obesity and white adipose tissue inflammation on the omental microenvironment in endometrial cancer.Cancer · 2022Article
- Rise in oral cancer risk factors associated with the COVID-19 pandemic mandates a more diligent approach to oral cancer screening and treatment.Journal of the American Dental Association (1939) · 2022Article
- Omental Macrophagic "Crown-like Structures" Are Associated with Poor Prognosis in Advanced-Stage Serous Ovarian Cancer.Current oncology (Toronto, Ont.) · 2021Article
- Diet-induced obesity accelerates oral carcinogenesis by recruitment and functional enhancement of myeloid-derived suppressor cells.Cell death & disease · 2021Article
- Early Childhood Fat Tissue Changes-Adipocyte Morphometry, Collagen Deposition, and Expression of CD163International journal of environmental research and public health · 2021Article
- Influence of Body Mass Index on Survival and Prognosis in Squamous Cell Carcinoma of Head and Neck.Cancer management and research · 2020Article
- Lessons from Hippocrates: Time to Change the Cancer Paradigm.International journal of chronic diseases · 2020Review
- The Effects of Adipocytes on the Regulation of Breast Cancer in the Tumor Microenvironment: An Update.Cells · 2019Review
- Supplemental estrogen and caloric restriction reduce obesity-induced periprostatic white adipose inflammation in mice.Carcinogenesis · 2019Article
- The obese adipose tissue microenvironment in cancer development and progression.Nature reviews. Endocrinology · 2019Review
- Article
- Pioglitazone Inhibits Periprostatic White Adipose Tissue Inflammation in Obese Mice.Cancer prevention research (Philadelphia, Pa.) · 2018Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundObesity is associated with increased adipose tissue in the tongue. Chronic white adipose tissue (WAT) inflammation commonly occurs in the obese. We investigated whether WAT inflammation in the tongue impacts survival in patients with squamous cell carcinoma (SCC) of the oral tongue.
methodsIn a retrospective cohort study, patients with T1 and T2 SCC of the oral tongue who underwent curative-intent resection were included. Tongue WAT inflammation was defined by the presence of dead or dying adipocytes surrounded by macrophages forming crown-like structures. The primary and secondary endpoints were disease-specific survival (DSS) and overall survival (OS), respectively. Subgroup analyses were carried out in patients without lymph node involvement for whom adjuvant therapies were not indicated.
resultsArchived tissue was available from 125 patients. The median follow-up was 55 months (range, 3-156 months). Overall, 49 of 125 patients (39%) had tongue WAT inflammation, which was associated with higher body mass index, increased tumor thickness, and vascular invasion (P < .05). The 3-year DSS rate for patients with tongue WAT inflammation was 59% (95% confidence interval [CI], 46%-76%) versus 82% (95% CI, 73%-92%) for those without inflammation. For patients without lymph node involvement for whom adjuvant therapy was not indicated (N = 70), tongue WAT inflammation was associated with shortened DSS and OS (P < .05). When adjusted for body mass index and potential prognostic covariates, the hazard ratio for DSS and OS was 5.40 (95% CI, 1.20-24.26) and 2.97 (95% CI, 1.02-8.65), respectively.
conclusionsTongue WAT inflammation is associated with worse DSS and OS in patients who have early stage SCC of the oral tongue. Cancer 2016;122:3794-3802. © 2016 American Cancer Society.
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Registered trials
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