Evidence map›Paper›PMID 27508089›Full record

ArticleWestern Pacific surveillance and response journal : WPSAR

Prevalence of resistance to second-line tuberculosis drug among multidrug-resistant tuberculosis patients in Viet Nam, 2011.

Hoa Binh Nguyen, Nhung Viet Nguyen, Huong Thi Giang Tran, Hai Viet Nguyen, Quyen Thi Tu Bui

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Article in Western Pacific surveillance and response journal : WPSAR. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Epidemiology of extensively drug-resistant tuberculosis among patients with multidrug-resistant tuberculosis: A systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hoa Binh NguyenNational Tuberculosis Control Programme Viet Nam, Hanoi, Viet Nam.; Centre for Operational Research, International Union Against Tuberculosis and Lung Disease, Paris, France.
Nhung Viet NguyenNational Tuberculosis Control Programme Viet Nam, Hanoi, Viet Nam.; Viet Nam Association for Tuberculosis and Lung Disease, Hanoi, Viet Nam.
Huong Thi Giang TranMinistry of Health, Department of International Cooperation, Viet Nam .
Hai Viet NguyenHanoi Medical University, Hanoi, Viet Nam .
Quyen Thi Tu BuiHanoi School of Public Health, Hanoi, Viet Nam .

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionExtensively drug-resistant tuberculosis (XDR-TB) represents an emerging public health problem worldwide. According to the World Health Organization, an estimated 9.7% of multidrug-resistant TB (MDR-TB) cases are defined as XDR-TB globally. The objective of this study was to determine the prevalence of drug resistance to second-line TB drugs among MDR-TB cases detected in the Fourth National Anti-Tuberculosis Drug Resistance Survey in Viet Nam.

methodsEighty clusters of TB cases were selected using a probability-proportion-to-size approach. To identify MDR-TB cases, drug susceptibility testing (DST) was performed for the four major first-line TB drugs. DST of second-line drugs (ofloxacin, amikacin, kanamycin, capreomycin) was performed on isolates from MDR-TB cases to identify pre-XDR and XDR cases.

resultsA total of 1629 smear-positive TB cases were eligible for culture and DST. Of those, DST results for first-line drugs were available for 1312 cases, and 91 (6.9%) had MDR-TB. Second-line DST results were available for 84 of these cases. Of those, 15 cases (17.9%) had ofloxacin resistance and 6.0% were resistant to kanamycin and capreomycin. Five MDR-TB cases (6.0%) met the criteria of XDR-TB.

conclusionThis survey provides the first estimates of the proportion of XDR-TB among MDR-TB cases in Viet Nam and provides important information for local policies regarding second-line DST. Local policies and programmes that are geared towards TB prevention, early diagnosis and treatment with effective regimens are of high importance.

Indexed as

AdultAgedAged, 80 and overAntitubercular AgentsCross-Sectional StudiesDrug Resistance, Multiple, BacterialExtensively Drug-Resistant TuberculosisFemaleHumansMaleMiddle AgedMycobacterium tuberculosisPrevalenceVietnamYoung AdultAntitubercular Agents

Identifiers

PMID27508089
PMCPMC4957611

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.