ArticleAmerican journal of translational research2016
SRT1720, a SIRT1 specific activator, protected H2O2-induced senescent endothelium.
Article in American journal of translational research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics.Pharmacology & therapeutics · 2019Pooled it
- Sirt1 transgene delivery improves diabetes-impaired wound healing.Bioactive materials · 2026Article
- NCardiovascular diabetology · 2025Article
- Review
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- Genistein alleviates HPharmaceutical biology · 2021Article
- γ- and δ-Tocotrienols interfere with senescence leading to decreased viability of cells.Molecular and cellular biochemistry · 2021Article
- The road ahead for health and lifespan interventions.Ageing research reviews · 2020Review
- Article
- The Role of Sirtuin1 in Regulating Endothelial Function, Arterial Remodeling and Vascular Aging.Frontiers in physiology · 2019Review
- The role of different SIRT1-mediated signaling pathways in toxic injury.Cellular & molecular biology letters · 2019Review
- CYP1B1 deiciency ameliorates learning and memory deficits caused by high fat diet in mice.American journal of translational research · 2019Article
- Kallistatin attenuates endothelial senescence by modulating Let-7g-mediated miR-34a-SIRT1-eNOS pathway.Journal of cellular and molecular medicine · 2018Article
- Comparative study of nanostructured carriers of calcium phosphate and magnesium phosphate loaded with SRT1720 for the protection of HAmerican journal of translational research · 2018Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Silent information regulator 1 (SIRT1) plays a critical role in maintaining vascular homeostasis via modulating senescent-related signal pathway, however, the molecular mechanism remains modest clarified. The purpose of this study was to examine whether SIRT1 specific activator SRT1720 would exhibit pro-angiogenic and anti-aging properties in response to hydrogen peroxide (H2O2)-induced endothelial senescence, and determine the underlying mechanisms. We pre-treated senescent human umbilical vein endothelial cells (HUVECs) with SRT1720, senescence-associated beta-galactosidase activity, apoptosis, migration, tube formation, proliferation and angiogenic factors were quantitatively examined. The results revealed that pharmacologic activation of SIRT1 by SRT1720 rescued apoptotic HUVECs and upregulated angiogenic response through reinforcing the protein expressions of angiogenic and survival factors in vitro. Furthermore, we confirmed that the expressions of endothelial nitric oxide synthase (eNOS), vascular endothelial growth factor (VEGF) and phosphoryl-Akt were augmented in SRT1720-treated senescent HUVECs. In conclusion, our data indicated that SRT1720 could protect against endothelial senescence and maintain cell function via Akt/eNOS/VEGF axis.
Indexed as
Identifiers
27508009PMC4969425What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.