ReviewNutrition & metabolism2016
Precipitating factors and targeted therapies in combating the perils of sickle cell disease--- A special nutritional consideration.
Review in Nutrition & metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Changing the Sickle Cell Nutrition Integration Narrative: Qualitative Perspectives From Sickle Cell Service Users/Carers About Nutritional Care.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026Article
- Knowledge and nutrition-related practices among caregivers of adolescents with sickle cell disease in the Greater Accra region of Ghana.BMC public health · 2023Article
- First Clinical Nutrition Outpatient Consultation: A Review of Basic Principles in Nutritional Care of Adults with Hematologic Disease.TheScientificWorldJournal · 2023Review
- Single-center experience of LVAD implantation in patients with sickle-cell trait: A retrospective analysis.Journal of cardiac surgery · 2022Observational
- Functional foods: promising therapeutics for Nigerian Children with sickle cell diseases.Heliyon · 2022Review
- Food insecurity, housing instability, and dietary quality among children with sickle cell disease: Assessment from a single urban center.Pediatric blood & cancer · 2022Article
- Pica in Pediatric Sickle Cell Disease.Journal of clinical psychology in medical settings · 2021Review
- Fruits and Vegetables in the Management of Underlying Conditions for COVID-19 High-Risk Groups.Foods (Basel, Switzerland) · 2021Review
- Toward a Conversational Agent to Support the Self-Management of Adults and Young Adults With Sickle Cell Disease: Usability and Usefulness Study.Frontiers in digital health · 2021Article
- Socioeconomic status dependent medical complexities in children with sickle cell disease in Saudi Arabia.Saudi journal of biological sciences · 2020Article
- Factors Influencing Motivation and Engagement in Mobile Health Among Patients With Sickle Cell Disease in Low-Prevalence, High-Income Countries: Qualitative Exploration of Patient Requirements.JMIR human factors · 2020Article
- In Vitro Lymphocyte Functions in Undernourished Children With Sickle Cell Anemia.Ochsner journal · 2020Article
- Effects of living at moderate altitude on pulmonary vascular function and exercise capacity in mice with sickle cell anaemia.The Journal of physiology · 2019Article
- Current therapies in alleviating liver disorders and cancers with a special focus on the potential of vitamin D.Nutrition & metabolism · 2018Review
- Hemoglobinopathies: ocular manifestations in children and adolescents.Therapeutic advances in ophthalmologyReview
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nutritional research in sickle cell disease has been the focus in recent times owing to not only specific nutritional deficiencies, but also the improvements associated with less painful episodes. Though hydroxyurea remains the drug of choice, certain adverse health effects on long term supplementation makes room for researches of different compounds. Macro and micro nutrient deficiencies, along with vitamins, play an important role in not only meeting the calorific needs, but also reducing clinical complications and growth abnormalities. Symptoms of hyper protein metabolism, increased cell turnover, increased cardiac output, and appetite suppression due to enhanced cytokine production, might give us leads for better understanding of the mechanisms involved. Different nutritional approaches comprising of traditional herbal therapies, antioxidants, flavonoids, vitamins, minerals etc., reducing oxidative stress and blood aggregation, have been tried out to increase the health potential. Nutritional therapies may also serve complementary to the newer therapies using ozone, hematopoietic stem cell transplantation, antifungal medications, erythropoietin etc. Herein we try to present a holistic picture of the different patho-physiological mechanisms, and nutritional strategies adopted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.