ReviewFrontiers in genetics2016
Spatial Genome Organization and Its Emerging Role as a Potential Diagnosis Tool.
Review in Frontiers in genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Alterations in Genome Organization in Lymphoma Cell Nuclei due to the Presence of the t(14;18) Translocation.International journal of molecular sciences · 2024Article
- Review
- Large-scale mapping of positional changes of hypoxia-responsive genes upon activation.Molecular biology of the cell · 2022Article
- Altered nuclear architecture in blood cells from Huntington's disease patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Genome-wide mapping of genomic DNA damage: methods and implications.Cellular and molecular life sciences : CMLS · 2021Review
- Label-free microscopy of mitotic chromosomes using the polarization orthogonality breaking technique.Biomedical optics express · 2021Article
- Assaying three-dimensional cellular architecture using X-ray tomographic and correlated imaging approaches.The Journal of biological chemistry · 2020Review
- Inferring chromosome radial organization from Hi-C data.BMC bioinformatics · 2020Article
- Spatial inter-centromeric interactions facilitated the emergence of evolutionary new centromeres.eLife · 2020Article
- The importance of the nuclear positioning of the PPARG gene for its expression during porcine in vitro adipogenesis.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2019Article
- The three-dimensional organization of the genome in cellular senescence and age-associated diseases.Seminars in cell & developmental biology · 2019Review
- Article
- Nuclear morphometrics and chromatin condensation patterns as disease biomarkers using a mobile microscope.PloS one · 2019Article
- Genome reorganization in different cancer types: detection of cancer specific breakpoint regions.Molecular cytogenetics · 2019Article
- Assessment of the Utility of Gene Positioning Biomarkers in the Stratification of Prostate Cancers.Frontiers in genetics · 2019Article
- Blank spots on the map: some current questions on nuclear organization and genome architecture.Histochemistry and cell biology · 2018Review
- 3D Shape Modeling for Cell Nuclear Morphological Analysis and Classification.Scientific reports · 2018Article
- The snail Biomphalaria glabrata as a model to interrogate the molecular basis of complex human diseases.PLoS neglected tropical diseases · 2018Article
- Nuclear organization during in vitro differentiation of porcine mesenchymal stem cells (MSCs) into adipocytes.Histochemistry and cell biology · 2018Article
- Protein sequestration at the nuclear periphery as a potential regulatory mechanism in premature aging.The Journal of cell biology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In eukaryotic cells the genome is highly spatially organized. Functional relevance of higher order genome organization is implied by the fact that specific genes, and even whole chromosomes, alter spatial position in concert with functional changes within the nucleus, for example with modifications to chromatin or transcription. The exact molecular pathways that regulate spatial genome organization and the full implication to the cell of such an organization remain to be determined. However, there is a growing realization that the spatial organization of the genome can be used as a marker of disease. While global genome organization patterns remain largely conserved in disease, some genes and chromosomes occupy distinct nuclear positions in diseased cells compared to their normal counterparts, with the patterns of reorganization differing between diseases. Importantly, mapping the spatial positioning patterns of specific genomic loci can distinguish cancerous tissue from benign with high accuracy. Genome positioning is an attractive novel biomarker since additional quantitative biomarkers are urgently required in many cancer types. Current diagnostic techniques are often subjective and generally lack the ability to identify aggressive cancer from indolent, which can lead to over- or under-treatment of patients. Proof-of-principle for the use of genome positioning as a diagnostic tool has been provided based on small scale retrospective studies. Future large-scale studies are required to assess the feasibility of bringing spatial genome organization-based diagnostics to the clinical setting and to determine if the positioning patterns of specific loci can be useful biomarkers for cancer prognosis. Since spatial reorganization of the genome has been identified in multiple human diseases, it is likely that spatial genome positioning patterns as a diagnostic biomarker may be applied to many diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.