ArticleFrontiers in plant science2016
Characterization of Shikonin Derivative Secretion in Lithospermum erythrorhizon Hairy Roots as a Model of Lipid-Soluble Metabolite Secretion from Plants.
Article in Frontiers in plant science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Molecules and Metabolites from Natural Products as Inhibitors of Biofilm in Candida spp. pathogens.Current topics in medicinal chemistry · 2019Pooled it
- Coupled mesoporous silica nanoparticles and limonene-chitosan Pickering emulsions: enhanced insecticidal delivery and selectivity.Journal of nanobiotechnology · 2026Article
- Modulation of microbial communication by lipid exudates.The ISME journal · 2026Review
- Characterization of two G-type half-size ABC transporter genes from the lipid-secreting medicinal plant Lithospermum erythrorhizon.Journal of plant research · 2025Article
- Visual analysis of research progress and trend on hairy roots.Frontiers in plant science · 2025Article
- Metabolites Obtained from Boraginaceae Plants as Potential Cosmetic Ingredients-A Review.Molecules (Basel, Switzerland) · 2024Review
- Effect of Silica Xerogel Functionalization on Intensification ofLife (Basel, Switzerland) · 2024Article
- Bacterial responses to plant antimicrobials: the case of alkannin and shikonin derivatives.Frontiers in pharmacology · 2023Article
- Arbuscular mycorrhizal fungi impact the production of alkannin/shikonin and their derivatives inFrontiers in microbiology · 2023Article
- Selective Impact of MTMS-Based Xerogel Morphology on Boosted Proliferation and Enhanced Naphthoquinone Production in Cultures ofInternational journal of molecular sciences · 2022Article
- Improved chemical fixation of lipid-secreting plant cells for transmission electron microscopy.Microscopy (Oxford, England) · 2022Article
- Inventory of ATP-binding cassette proteins in Lithospermum erythrorhizon as a model plant producing divergent secondary metabolites.DNA research : an international journal for rapid publication of reports on genes and genomes · 2022Article
- Inhibiting pyruvate kinase muscle isoform 2 regresses group 2 pulmonary hypertension induced by supra-coronary aortic banding.Acta physiologica (Oxford, England) · 2022Article
- Root-associated bacteria modulate the specialised metabolome ofFrontiers in plant science · 2022Article
- Hairy roots: An untapped potential for production of plant products.Frontiers in plant science · 2022Review
- MTMS-Based Aerogel Constructs for Immobilization of Plant Hairy Roots: Effects on Proliferation ofJournal of functional biomaterials · 2021Article
- Endophytic Bacteria From the Roots of the Medicinal PlantFrontiers in microbiology · 2021Article
- Establishment of the hairy root culture of3 Biotech · 2020Article
- Two BAHD Acyltransferases Catalyze the Last Step in the Shikonin/Alkannin Biosynthetic Pathway.Plant physiology · 2020Article
- Secondary metabolites as plant defensive strategy: a large role for small molecules in the near root region.Planta · 2020Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Shikonin derivatives are specialized lipophilic metabolites, secreted in abundant amounts from the root epidermal cells of Lithospermum erythrorhizon. Because they have anti-microbial activities, these compounds, which are derivatives of red naphthoquinone, are thought to serve as a chemical barrier for plant roots. The mechanism by which they are secreted from cells is, however, largely unknown. The shikonin production system in L. erythrorhizon is an excellent model for studying the mechanism by which lipophilic compounds are secreted from plant cells, because of the abundant amounts of these compounds produced by L. erythrorhizon, the 0 to 100% inducibility of their production, the light-specific inhibition of production, and the visibility of these products as red pigments. To date, many factors regulating shikonin biosynthesis have been identified, but no mechanism that regulates shikonin secretion without inhibiting biosynthesis has been detected. This study showed that inhibitors of membrane traffic strongly inhibit shikonin secretion without inhibiting shikonin production, suggesting that the secretion of shikonin derivatives into the apoplast utilizes pathways common to the ADP-ribosylation factor/guanine nucleotide exchange factor (ARF/GEF) system and actin filament polymerization, at least in part. These findings provide clues about the machinery involved in secreting lipid-soluble metabolites from cells.
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