ArticleFrontiers in microbiology2016
Flavoprotein-Mediated Tellurite Reduction: Structural Basis and Applications to the Synthesis of Tellurium-Containing Nanostructures.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Microbial mechanisms to transform the super-trace element tellurium: a systematic review and discussion of nanoparticulate phases.World journal of microbiology & biotechnology · 2023Pooled it
- Characterization of Tellurite Toxicity toInternational journal of molecular sciences · 2025Article
- Biosynthesis of Gold Nanostructures and Their Virucidal Activity Against Influenza A Virus.International journal of molecular sciences · 2025Article
- Exploring the Potential of Glutathione Reductase Overexpression to Improve Tellurium Nanoparticle Production inInternational journal of molecular sciences · 2025Article
- Computer simulation study of nutrient-driven bacterial biofilm stratification.Journal of the Royal Society, Interface · 2024Article
- The crystal structure of mycothiol disulfide reductase (Mtr) provides mechanistic insight into the specific low-molecular-weight thiol reductase activity of Actinobacteria.Acta crystallographica. Section D, Structural biology · 2024Article
- Comparative Analysis of Stable Gold Nanoparticles Synthesized Using Sonochemical and Reduction Methods for Antibacterial Activity.Molecules (Basel, Switzerland) · 2023Article
- Selective bacterial separation of critical metals: towards a sustainable method for recycling lithium ion batteries.Green chemistry : an international journal and green chemistry resource : GC · 2022Article
- Tellurite and Selenite: how can these two oxyanions be chemically different yet so similar in the way they are transformed to their metal forms by bacteria?Biological research · 2022Review
- Anaerobic RSH-dependent tellurite reduction contributes to Escherichia coli tolerance against tellurite.Biological research · 2022Article
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- Green Synthesis of Selenium and Tellurium Nanoparticles: Current Trends, Biological Properties and Biomedical Applications.International journal of molecular sciences · 2021Review
- Impact of Tellurite on the Metabolism ofFrontiers in microbiology · 2021Article
- Reduction of Gold (III) and Tellurium (IV) byFrontiers in microbiology · 2018Article
- Synthesis and Antibacterial Activity of Metal(loid) Nanostructures by Environmental Multi-Metal(loid) Resistant Bacteria and Metal(loid)-Reducing Flavoproteins.Frontiers in microbiology · 2018Article
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Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tellurium oxyanion tellurite (TeO3 (2-)) is extremely harmful for most organisms. It has been suggested that a potential bacterial tellurite resistance mechanism would consist of an enzymatic, NAD(P)H-dependent, reduction to the less toxic form elemental tellurium (Te(0)). To date, a number of enzymes such as catalase, type II NADH dehydrogenase and terminal oxidases from the electron transport chain, nitrate reductases, and dihydrolipoamide dehydrogenase (E3), among others, have been shown to display tellurite-reducing activity. This activity is generically referred to as tellurite reductase (TR). Bioinformatic data resting on some of the abovementioned enzymes enabled the identification of common structures involved in tellurite reduction including vicinal catalytic cysteine residues and the FAD/NAD(P)(+)-binding domain, which is characteristic of some flavoproteins. Along this line, thioredoxin reductase (TrxB), alkyl hydroperoxide reductase (AhpF), glutathione reductase (GorA), mercuric reductase (MerA), NADH: flavorubredoxin reductase (NorW), dihydrolipoamide dehydrogenase, and the putative oxidoreductase YkgC from Escherichia coli or environmental bacteria were purified and assessed for TR activity. All of them displayed in vitro TR activity at the expense of NADH or NADPH oxidation. In general, optimal reducing conditions occurred around pH 9-10 and 37°C. Enzymes exhibiting strong TR activity produced Te-containing nanostructures (TeNS). While GorA and AhpF generated TeNS of 75 nm average diameter, E3 and YkgC produced larger structures (>100 nm). Electron-dense structures were observed in cells over-expressing genes encoding TrxB, GorA, and YkgC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.