ArticleFrontiers in human neuroscience2016
Neural Correlates of Fear of Movement in Patients with Chronic Low Back Pain vs. Pain-Free Individuals.
Article in Frontiers in human neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Neural activity differences and their functional and clinical correlates after anterior cruciate ligament reconstruction: A systematic review of task-based fMRI studies.Experimental brain research · 2026Pooled it
- Age as a Mediator of tDCS Effects on Pain: An Integrative Systematic Review and Meta-Analysis.Frontiers in human neuroscience · 2020Pooled it
- Trial
- Association between pain, physical performance, and kinesiophobia in older women with low back pain: A cross-sectional study.PloS one · 2026Article
- Article
- Article
- Exploring the associations of cortical connectivity-modulation with clinical and psychological measures in acute low back pain.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Work-Related Low Back Pain Among Physical Therapists in the Makkah Region, Saudi Arabia: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2025Article
- Sleep architecture and quality and pain experience in individuals with persistent low back pain and asymptomatic controls.PloS one · 2025Article
- Dual analysis of postural control in middle-aged and elderly patients with cervicogenic dizziness: Dynamic and static balance perspectives.Frontiers in bioengineering and biotechnology · 2025Article
- Regulation of static and dynamic balance in healthy young adults: interactions between stance width and visual conditions.Frontiers in bioengineering and biotechnology · 2025Article
- From taboo to treatment: The emergence of psychedelics in the management of pain and opioid use disorder.British journal of clinical pharmacology · 2024Review
- Inhibition of Canonical Transient Receptor Potential Channels 4/5 with Highly Selective and Potent Small-Molecule HC-070 Alleviates Mechanical Hypersensitivity in Rat Models of Visceral and Neuropathic Pain.International journal of molecular sciences · 2023Article
- The relationship between drop vertical jump action-observation brain activity and kinesiophobia after anterior cruciate ligament reconstruction: A cross-sectional fMRI study.Brain and behavior · 2023Article
- Adaptive changes in sensorimotor processing in patients with acute low back pain.Scientific reports · 2022Article
- An Investigation of the Nature of Fear within ACL-Injured Subjects When Exposed to Provocative Videos: A Concurrent Qualitative and Quantitative Study.Sports (Basel, Switzerland) · 2022Article
- Fear Extinction-Based Inter-Individual and Sex Differences in Pain-Related Vocalizations and Anxiety-like Behaviors but Not Nocifensive Reflexes.Brain sciences · 2021Article
- Pain Neuroscience Education Delivered by a Student Physical Therapist for a Patient with Persistent Musculoskeletal Pain.The American journal of case reports · 2021Article
- Fear of movement is associated with corticomotor depression in response to acute experimental muscle pain.Experimental brain research · 2020Article
- The Bed Nucleus of the Stria Terminalis as a Brain Correlate of Psychological Inflexibility in Fibromyalgia.Journal of clinical medicine · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fear of movement (FOM) can be acquired by a direct aversive experience such as pain or by social learning through observation and instruction. Excessive FOM results in heightened disability and is an obstacle for recovery from acute, subacute, and chronic low back pain (cLBP). FOM has further been identified as a significant explanatory factor in the Fear Avoidance (FA) model of cLBP that describes how individuals experiencing acute back pain may become trapped into a vicious circle of chronic disability and suffering. Despite a wealth of evidence emphasizing the importance of FOM in cLBP, to date, no related neural correlates in patients were found and this therefore has initiated a debate about the precise contribution of fear in the FA model. In the current fMRI study, we applied a novel approach encompassing: (1) video clips of potentially harmful activities for the back as FOM inducing stimuli; and (2) the assessment of FOM in both, cLBP patients (N = 20) and age- and gender-matched pain-free subjects (N = 20). Derived from the FA model, we hypothesized that FOM differentially affects brain regions involved in fear processing in patients with cLBP compared to pain-free individuals due to the recurrent pain and subsequent avoidance behavior. The results of the whole brain voxel-wise regression analysis revealed that: (1) FOM positively correlated with brain activity in fear-related brain regions such as the amygdala and the insula; and (2) differential effects of FOM between patients with cLBP and pain-free subjects were found in the extended amygdala and in its connectivity to the anterior insula. Current findings support the FOM component of the FA model in cLBP.
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