ArticleFrontiers in human neuroscience2016
A Direct Cortico-Nigral Pathway as Revealed by Constrained Spherical Deconvolution Tractography in Humans.
Article in Frontiers in human neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- A transcriptional program associated with neurotransmission in the living human brain.Molecular psychiatry · 2026Article
- The active role of non-synaptic electromagnetic induction in modulating absence epilepsy: a kinetic modeling study.Biological cybernetics · 2026Article
- Iron concentration in the ventral pallidum of chronic migraine with medication-overuse headache.The journal of headache and pain · 2026Article
- Evidence for direct dopaminergic connections between substantia nigra pars compacta and thalamus in young healthy humans.Frontiers in neural circuits · 2024Article
- In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain-striatum-cortex assembloids.Nature methods · 2023Article
- Motor cortical excitability and pre-supplementary motor area neurochemistry in healthy adults with substantia nigra hyperechogenicity.Journal of neuroscience research · 2023Article
- Basal ganglia for beginners: the basic concepts you need to know and their role in movement control.Frontiers in systems neuroscience · 2023Review
- White matter hyperintensities burden in the frontal regions is positively correlated to the freezing of gait in Parkinson's disease.Frontiers in aging neuroscience · 2023Article
- Role of the nigrosome 1 absence as a biomarker in amyotrophic lateral sclerosis.Journal of neurology · 2022Article
- Striatal topographical organization: Bridging the gap between molecules, connectivity and behavior.European journal of histochemistry : EJH · 2021Review
- Red nucleus structure and function: from anatomy to clinical neurosciences.Brain structure & function · 2021Review
- The Cerebellar Dopaminergic System.Frontiers in systems neuroscience · 2021Review
- Histological and Immunofluorescence Study of Discal Ligaments in Human Temporomandibular Joint.Journal of functional morphology and kinesiology · 2020Article
- Spatially coherent and topographically organized pathways of the human globus pallidus.Human brain mapping · 2020Article
- In Vivo Computed Tomography Direct Volume Rendering of the Anterior Ethmoidal Artery: A Descriptive Anatomical Study.International archives of otorhinolaryngology · 2020Article
- Altered functional connectivity of the red nucleus and substantia nigra in migraine without aura.The journal of headache and pain · 2019Article
- The cortico-rubral and cerebello-rubral pathways are topographically organized within the human red nucleus.Scientific reports · 2019Article
- Neural Circuit and Clinical Insights from Intraoperative Recordings During Deep Brain Stimulation Surgery.Brain sciences · 2019Article
- Mapping the structural connectivity between the periaqueductal gray and the cerebellum in humans.Brain structure & function · 2019Article
- The Cortico-Basal Ganglia-Cerebellar Network: Past, Present and Future Perspectives.Frontiers in systems neuroscience · 2019Article
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12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Substantia nigra is an important neuronal structure, located in the ventral midbrain, that exerts a regulatory function within the basal ganglia circuitry through the nigro-striatal pathway. Although its subcortical connections are relatively well-known in human brain, little is known about its cortical connections. The existence of a direct cortico-nigral pathway has been demonstrated in rodents and primates but only hypothesized in humans. In this study, we aimed at evaluating cortical connections of substantia nigra in vivo in human brain by using probabilistic constrained spherical deconvolution (CSD) tractography on magnetic resonance diffusion weighted imaging data. We found that substantia nigra is connected with cerebral cortex as a whole, with the most representative connections involving prefrontal cortex, precentral and postcentral gyri and superior parietal lobule. These results may be relevant for the comprehension of the pathophysiology of several neurological disorders involving substantia nigra, such as parkinson's disease, schizophrenia, and pathological addictions.
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