ArticleFrontiers in human neuroscience2016
Increased Functional Activation of Limbic Brain Regions during Negative Emotional Processing in Migraine.
Article in Frontiers in human neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Impact of chronic migraine attacks and their severity on the endogenous μ-opioid neurotransmission in the limbic system.NeuroImage. Clinical · 2019Trial
- Migraine and auditory dysfunction: beyond comorbidity.Journal of neurology · 2026Review
- Early life stress induces brain-wide electrical network predisposition to migraine.The journal of headache and pain · 2026Article
- Sex-dependent central amygdala physiology after supradural CGRP exposure is associated with migraine-like behaviors.The journal of headache and pain · 2026Article
- Clinical features of chronic tension-type headache combined with hyperacusis: a cross-sectional study.Sao Paulo medical journal = Revista paulista de medicina · 2026Article
- Case Report: A reversible autonomic-endothelial migraine pattern: a conceptual perspective illustrated by a clinical case.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Mechanistic intersections between migraine and major depressive disorder.The journal of headache and pain · 2025Review
- Regional and whole-brain neurofunctional alterations during pain empathic processing of physical but not affective pain in migraine patients.The journal of headache and pain · 2025Article
- Differential fMRI neural synchrony associated with migraine during naturalistic stimuli with negative emotional valence.The journal of headache and pain · 2025Article
- Children and adolescents with primary headaches exhibit altered sensory profiles - a multi-modal investigation.The journal of headache and pain · 2024Article
- Article
- Galcanezumab effects on incidence of headache after occurrence of triggers, premonitory symptoms, and aura in responders, non-responders, super-responders, and super non-responders.The journal of headache and pain · 2023Observational
- A study on alterations in functional activity in migraineurs during the interictal period.Heliyon · 2023Article
- Altered effective connectivity in migraine patients during emotional stimuli: a multi-frequency magnetoencephalography study.The journal of headache and pain · 2022Article
- Association of plasma tryptophan concentration with periaqueductal gray matter functional connectivity in migraine patients.Scientific reports · 2022Article
- Causal Structural Covariance Network Suggesting Structural Alterations Progression in Type 2 Diabetes Patients.Frontiers in human neuroscience · 2022Article
- Early Onset Diffusion Abnormalities in Refractory Headache Disorders.Frontiers in neurology · 2022Article
- Circadian Variation of Migraine Attack Onset Affects fMRI Brain Response to Fearful Faces.Frontiers in human neuroscience · 2022Article
- Disrupted Dynamic Functional Connectivity of the Visual Network in Episodic Patients with Migraine without Aura.Neural plasticity · 2022Article
- The contribution of the left precuneus to emotion memory in migraine without aura patients.Frontiers in neuroscience · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Pain is both an unpleasant sensory and emotional experience. This is highly relevant in migraine where cortical hyperexcitability in response to sensory stimuli (including pain, light, and sound) has been extensively reported. However, migraine may feature a more general enhanced response to aversive stimuli rather than being sensory-specific. To this end we used functional magnetic resonance imaging to assess neural activation in migraineurs interictaly in response to emotional visual stimuli from the International Affective Picture System. Migraineurs, compared to healthy controls, demonstrated increased neural activity in response to negative emotional stimuli. Most notably in regions overlapping in their involvement in both nociceptive and emotional processing including the posterior cingulate, caudate, amygdala, and thalamus (cluster corrected, p < 0.01). In contrast, migraineurs and healthy controls displayed no and minimal differences in response to positive and neutral emotional stimuli, respectively. These findings support the notion that migraine may feature more generalized altered cerebral processing of aversive/negative stimuli, rather than exclusively to sensory stimuli. A generalized hypersensitivity to aversive stimuli may be an inherent feature of migraine, or a consequential alteration developed over the duration of the disease. This proposed cortical-limbic hypersensitivity may form an important part of the migraine pathophysiology, including psychological comorbidity, and may represent an innate sensitivity to aversive stimuli that underpins attack triggers, attack persistence and (potentially) gradual headache chronification.
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