ArticleNucleic acids research2017
ADPriboDB: The database of ADP-ribosylated proteins.
Article in Nucleic acids research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Noncovalent PAR Binding Guides Proteins to PARP1-Mediated PARylation.ACS chemical biology · 2026Article
- Nuclear poly(A)-binding protein and nucleolin utilize their RNA recognition motifs to read PAR chains.Nucleic acids research · 2025Article
- PARP4 interacts with hnRNPM to regulate splicing during lung cancer progression.Genome medicine · 2024Article
- PARPs and ADP-Ribosylation in Chronic Inflammation: A Focus on Macrophages.Pathogens (Basel, Switzerland) · 2023Review
- PARP12 is required for mitochondrial function maintenance in thermogenic adipocytes.Adipocyte · 2022Article
- mTORC1-c-Myc pathway rewires methionine metabolism for HCC progression through suppressing SIRT4 mediated ADP ribosylation of MAT2A.Cell & bioscience · 2022Article
- PARP1 proximity proteomics reveals interaction partners at stressed replication forks.Nucleic acids research · 2022Article
- A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A.The EMBO journal · 2022Article
- Poly(ADP-ribose) promotes toxicity ofScience translational medicine · 2022Article
- Multi-omics approaches for biomarker discovery in early ovarian cancer diagnosis.EBioMedicine · 2022Review
- Current status of PTMs structural databases: applications, limitations and prospects.Amino acids · 2022Review
- Neuralized-like protein 4 (NEURL4) mediates ADP-ribosylation of mitochondrial proteins.The Journal of cell biology · 2022Article
- The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.Nature cell biology · 2022Article
- Deficiency of PARP-1 and PARP-2 in the mouse uterus results in decidualization failure and pregnancy loss.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Molecular Tools for the Study of ADP-Ribosylation: A Unified and Versatile Method to Synthesise Native Mono-ADP-Ribosylated Peptides.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- ADPriboDB 2.0: an updated database of ADP-ribosylated proteins.Nucleic acids research · 2021Article
- ADPriboDB v2.0: An Updated Database of ADP-ribosylated Proteins.bioRxiv : the preprint server for biology · 2020Article
- Dynamic ADP-Ribosylome, Phosphoproteome, and Interactome in LPS-Activated Macrophages.Journal of proteome research · 2020Article
- Poly(ADP-ribose): A Dynamic Trigger for Biomolecular Condensate Formation.Trends in cell biology · 2020Review
- Proteomics of Long-Lived Mammals.Proteomics · 2020Review
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
ADP-ribosylation refers to the addition of one or more ADP-ribose units onto proteins post-translationally. This protein modification is often added by ADP-ribosyltransferases, commonly known as PARPs, but it can also be added by other enzymes, including sirtuins or bacterial toxins. While past literature has utilized a variety of methods to identify ADP-ribosylated proteins, recent proteomics studies bring the power of mass spectrometry to determine sites of the modification. To appreciate the diverse roles of ADP-ribosylation across the proteome, we have created ADPriboDB - a database of ADP-ribosylated proteins (http://ADPriboDB.leunglab.org). Each entry of ADPriboDB is annotated manually by at least two independent curators from the literature between January 1975 and July 2015. The current database includes over 12 400 protein entries from 459 publications, identifying 2389 unique proteins. Here, we describe the structure and the current state of ADPriboDB as well as the criteria for entry inclusion. Using this aggregate data, we identified a statistically significant enrichment of ADP-ribosylated proteins in non-membranous RNA granules. To our knowledge, ADPriboDB is the first publicly available database encapsulating ADP-ribosylated proteins identified from the past 40 years, with a hope to facilitate the research of both basic scientists and clinicians to better understand ADP-ribosylation at the molecular level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.