Evidence map›Paper›PMID 27507701›Full record

ArticleMolecular genetics and genomics : MGG2016

Genetic differentiation and population structure of five ethnic groups of Punjab (North-West India).

Gagandeep Singh, Indu Talwar, Rubina Sharma, Kawaljit Matharoo, A J S Bhanwer

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Article in Molecular genetics and genomics : MGG, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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3citing papers in PubMed
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3 · Its place in the literature

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3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Gagandeep SinghDepartment of Anthropology, Panjab University, Chandigarh, 160014, India.
Indu TalwarDepartment of Anthropology, Panjab University, Chandigarh, 160014, India.
Rubina SharmaDepartment of Human Genetics, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.
Kawaljit MatharooDepartment of Human Genetics, Guru Nanak Dev University, Amritsar, Punjab, 143005, India. matharookawal@gmail.com.
A J S BhanwerDepartment of Human Genetics, Guru Nanak Dev University, Amritsar, Punjab, 143005, India. ajsbhanwer@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The state of Punjab in the North-West part of India has acted as the main passage for all the major human invasions into the Indian subcontinent. It has resulted in the mixing of foreign gene pool into the local populations, which led to an extensive range of genetic diversity and has influenced the genetic structure of populations in Punjab, North-West India. The present study was conducted to examine the genetic structure, relationships, and extent of genetic differentiation in five Indo-European speaking ethnic groups of Punjab. A total of 1021 unrelated samples belonging to Banias, Brahmins, Jat Sikhs, Khatris, and Scheduled castes were analyzed for four human-specific Ins/Del polymorphic loci (ACE, APO, PLAT, and D1) and three restriction fragment length polymorphisms ESR (PvuII), LPL (PvuII), and T2 (MspI) using Polymerase chain reaction (PCR). All the loci were found to be polymorphic among the studied populations. The frequency of the Alu insertion at APO locus was observed to exhibit the highest value (82.6-96.3 %), whereas D1 exhibited the lowest (26.5-45.6 %) among all the ethnic groups. The average heterozygosity among the studied populations ranged from 0.3816 in Banias to 0.4163 in Khatris. The F

Indexed as

Genetic VariationGene FrequencyGenetic DriftGenetics, PopulationHumansINDEL MutationIndiaPhylogenyPolymorphism, Restriction Fragment LengthWhite PeopleAlu Insertion/deletionEthnic groupGenetic diversityNorth-West IndiaSNP

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PMID27507701

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