ArticleScientific reports2016
Detection of inflammatory cell function using (13)C magnetic resonance spectroscopy of hyperpolarized [6-(13)C]-arginine.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
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- Metabolic response to radiation therapy in cancer.Molecular carcinogenesis · 2022Review
- Parahydrogen-Induced Polarization of Amino Acids.Angewandte Chemie (International ed. in English) · 2021Review
- Non-Invasive Differentiation of M1 and M2 Activation in Macrophages Using HyperpolarizedMetabolites · 2021Article
- HyperpolarizedNMR in biomedicine · 2021Review
- Fueling the Revolution: Targeting Metabolism to Enhance Immunotherapy.Cancer immunology research · 2021Review
- Imaging Brain Metabolism Using HyperpolarizedTrends in neurosciences · 2020Review
- Metabolic Imaging and Biological Assessment: Platforms to Evaluate Acute Lung Injury and Inflammation.Frontiers in physiology · 2020Review
- Multimodality Hyperpolarized C-13 MRS/PET/Multiparametric MR Imaging for Detection and Image-Guided Biopsy of Prostate Cancer: First Experience in a Canine Prostate Cancer Model.Molecular imaging and biology · 2019Article
- HyperpolarizedRadiology · 2019Review
- Hyperpolarized [6-ACS chemical biology · 2019Article
- Assessing Therapeutic Efficacy in Real-time by Hyperpolarized Magnetic Resonance Metabolic Imaging.Cells · 2019Review
- HyperpolarizedNeoplasia (New York, N.Y.) · 2019Review
- Monitoring the Neuroinflammatory Response Following Acute Brain Injury.Frontiers in neurology · 2017Review
- Nanoparticle-Based Magnetic Resonance Imaging on Tumor-Associated Macrophages and Inflammation.Frontiers in immunology · 2017Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Myeloid-derived suppressor cells (MDSCs) are highly prevalent inflammatory cells that play a key role in tumor development and are considered therapeutic targets. MDSCs promote tumor growth by blocking T-cell-mediated anti-tumoral immune response through depletion of arginine that is essential for T-cell proliferation. To deplete arginine, MDSCs express high levels of arginase, which catalyzes the breakdown of arginine into urea and ornithine. Here, we developed a new hyperpolarized (13)C probe, [6-(13)C]-arginine, to image arginase activity. We show that [6-(13)C]-arginine can be hyperpolarized, and hyperpolarized [(13)C]-urea production from [6-(13)C]-arginine is linearly correlated with arginase concentration in vitro. Furthermore we show that we can detect a statistically significant increase in hyperpolarized [(13)C]-urea production in MDSCs when compared to control bone marrow cells. This increase was associated with an increase in intracellular arginase concentration detected using a spectrophotometric assay. Hyperpolarized [6-(13)C]-arginine could therefore serve to image tumoral MDSC function and more broadly M2-like macrophages.
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Registered trials
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