ArticleScientific reports2016
Gradient moduli lens models: how material properties and application of forces can affect deformation and distributions of stress.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- The Effect of Lens Shape, Zonular Insertion and Finite Element Model on Simulated Shape Change of the Eye Lens.Annals of biomedical engineering · 2024Article
- Functional effects of the spatial-varying lens mechanical properties in accommodation.JPhys photonics · 2024Article
- Design of an Automatically Controlled Multi-Axis Stretching Device for Mechanical Evaluations of the Anterior Eye Segment.Bioengineering (Basel, Switzerland) · 2023Article
- Insights into the biochemical and biophysical mechanisms mediating the longevity of the transparent optics of the eye lens.The Journal of biological chemistry · 2022Review
- Characterisation and Modelling of an Artificial Lens Capsule Mimicking Accommodation of Human Eyes.Polymers · 2021Article
- A numerical investigation of changes in lens shape during accommodation.Scientific reports · 2021Article
- Deformations and Ruptures in Human Lenses With Cortical Cataract Subjected to Ex Vivo Simulated Accommodation.Investigative ophthalmology & visual science · 2021Article
- The Structure of the Lens and Its Associations with the Visual Quality.BMJ open ophthalmology · 2020Review
- Image registration of the human accommodating eye demonstrates equivalent increases in lens equatorial radius and central thickness.International journal of ophthalmology · 2019Article
- The importance of parameter choice in modelling dynamics of the eye lens.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human lens provides one-third of the ocular focussing power and is responsible for altering focus over a range of distances. This ability, termed accommodation, defines the process by which the lens alters shape to increase or decrease ocular refractive power; this is mediated by the ciliary muscle through the zonule. This ability decreases with age such that around the sixth decade of life it is lost rendering the eye unable to focus on near objects. There are two opponent theories that provide an explanation for the mechanism of accommodation; definitive support for either of these requires investigation. This work aims to elucidate how material properties can affect accommodation using Finite Element models based on interferometric measurements of refractive index. Gradients of moduli are created in three models from representative lenses, aged 16, 35 and 48 years. Different forms of zonular attachments are studied to determine which may most closely mimic the physiological form by comparing stress and displacement fields with simulated shape changes to accommodation in living lenses. The results indicate that for models to mimic accommodation in living eyes, the anterior and posterior parts of the zonule need independent force directions. Choice of material properties affects which theory of accommodation is supported.
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