ArticleScientific reports2016
Controllable in-situ cell electroporation with cell positioning and impedance monitoring using micro electrode array.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Recent advances in microscale techniques for red blood cells manipulation.Biomicrofluidics · 2025Review
- Novel electroporation microchip with field constriction enhances transfection efficiency and survival rates of feline embryos.Scientific reports · 2024Article
- Transepithelial Electrical Impedance Increase Following Porous Substrate Electroporation Enables Label-Free Delivery.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Development of Specialized Microelectrode Arrays with Local Electroporation Functionality.Annals of biomedical engineering · 2024Article
- Electroactive nanoinjection platform for intracellular delivery and gene silencing.Journal of nanobiotechnology · 2023Article
- A review of bio-impedance devices.Medical & biological engineering & computing · 2023Review
- Recent Advances in Microscale Electroporation.Chemical reviews · 2022Review
- A label-free and low-power microelectronic impedance spectroscopy for characterization of exosomes.PloS one · 2022Article
- Ultralong-Time Recovery and Low-Voltage Electroporation for Biological Cell Monitoring Enabled by a Microsized Multipulse Framework.ACS omega · 2021Article
- Recent Advances in Electrical Impedance Sensing Technology for Single-Cell Analysis.Biosensors · 2021Review
- mRNA-based CAR T-cells manufactured by miniaturized two-step electroporation produce selective cytotoxicity toward target cancer cells.Lab on a chip · 2021Article
- In situ electroporation of mammalian cells through SiOScientific reports · 2021Article
- Microfluidic Based Physical Approaches towards Single-Cell Intracellular Delivery and Analysis.Micromachines · 2021Review
- Single-Cell Electroporation with Real-Time Impedance Assessment Using a Constriction Microchannel.Micromachines · 2020Article
- A Novel Electroporation System for Living Cell Staining and Membrane Dynamics Interrogation.Micromachines · 2020Article
- Single-cell individualized electroporation with real-time impedance monitoring using a microelectrode array chip.Microsystems & nanoengineering · 2020Article
- Printed Flexible Microelectrode for Application of Nanosecond Pulsed Electric Fields on Cells.Materials (Basel, Switzerland) · 2019Article
- A flow through device for simultaneous dielectrophoretic cell trapping and AC electroporation.Scientific reports · 2019Article
- Possible Effects of Electric Fields on a Pair of Spherical Cells.The Journal of membrane biology · 2017Article
- Recent Advances in the Analysis of Single Cells.Analytical chemistry · 2017Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper reports a novel microarray chip for in-situ, real-time and selective electroporation on individual cells integrated with cell positioning and impedance monitoring. An array of quadrupole-electrode units (termed positioning electrodes) and pairs of planar center electrodes located at the centers of each quadrupole-electrode unit were fabricated on the chip. The positioning electrodes are used to trap and position living cells onto the center electrodes based on negative dielectrophoresis (nDEP). The center electrodes are used for in-situ cell electroporation, and also used to measure cell impedance for monitoring cellular dynamics in real time. Controllably selective electroporation and electrical measurement on the cells in array are realized. We present an evidence of selective electroporation through use of fluorescent dyes. Subsequently we use in-situ and real-time impedance measurement to monitor the process, which demonstrates the dynamic behavior of the cell electroporation. Finally, we show the use of this device to perform successful transfection onto individual HeLa cells with vector DNA encoding a green fluorescent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.