ArticleScientific reports2016
"A novel highly stable and injectable hydrogel based on a conformationally restricted ultrashort peptide".
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Poly(L-Tyrosine)-Containing Dehydropeptides: Hydrogels vs. Bioadhesives.Gels (Basel, Switzerland) · 2026Article
- Ultra-Short Peptide Hydrogels as 3D Bioprinting Materials.Gels (Basel, Switzerland) · 2026Review
- Self-Assembly Pathway Influence on Dehydropeptide-Based Gel Properties and Drug Release.Macromolecular bioscience · 2025Article
- A Review on the Rheological Properties of Single Amino Acids and Short Dipeptide Gels.Gels (Basel, Switzerland) · 2024Review
- In Situ Synthesis and Self-Assembly of Peptide-PEG Conjugates: A Facile Method for the Construction of Fibrous Hydrogels.Biomacromolecules · 2024Article
- Review
- Modified dipeptide based nanospheres as a potent adjuvating delivery system for recombinant vaccines.Frontiers in drug delivery · 2023Article
- Conformationally Restricted Dipeptide-Based Nanoparticles for Delivery of siRNA in Experimental Liver Cirrhosis.ACS omega · 2022Article
- Biomaterials via peptide assembly: Design, characterization, and application in tissue engineering.Acta biomaterialia · 2022Review
- Supramolecular assembly of protein building blocks: from folding to function.Nano convergence · 2022Review
- NGIWY-Amide: A Bioinspired Ultrashort Self-Assembled Peptide Gelator for Local Drug Delivery Applications.Pharmaceutics · 2022Article
- Injectable Magnetic-Responsive Short-Peptide Supramolecular Hydrogels: Ex Vivo and In Vivo Evaluation.ACS applied materials & interfaces · 2021Article
- Synthesis, Characterization and Evaluation of Peptide Nanostructures for Biomedical Applications.Molecules (Basel, Switzerland) · 2021Review
- Article
- Metal Cation Triggered Peptide Hydrogels and Their Application in Food Freshness Monitoring and Dye Adsorption.Gels (Basel, Switzerland) · 2021Article
- Enhanced Delivery of Neuroactive Drugs via Nasal Delivery with a Self-Healing Supramolecular Gel.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Self-assembled peptide and protein nanostructures for anti-cancer therapy: Targeted delivery, stimuli-responsive devices and immunotherapy.Nano today · 2021Article
- Evaluation of a Model Photo-Caged Dehydropeptide as a Stimuli-Responsive Supramolecular Hydrogel.Nanomaterials (Basel, Switzerland) · 2021Article
- Dehydropeptide Supramolecular Hydrogels and Nanostructures as Potential Peptidomimetic Biomedical Materials.International journal of molecular sciences · 2021Review
- Enhancing Antimicrobial Peptide Potency through Multivalent Presentation on Coiled-Coil Nanofibrils.ACS medicinal chemistry letters · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanostructures including hydrogels based on peptides containing non protein amino acids are being considered as platform for drug delivery because of their inherent biocompatibility and additional proteolytic stability. Here we describe instantaneous self-assembly of a conformationally restricted dipeptide, LeuΔPhe, containing an α,β-dehydrophenylalanine residue into a highly stable and mechanically strong hydrogel, under mild physiological aqueous conditions. The gel successfully entrapped several hydrophobic and hydrophilic drug molecules and released them in a controlled manner. LeuΔPhe was highly biocompatible and easily injectable. Administration of an antineoplastic drug entrapped in the gel in tumor bearing mice significantly controlled growth of tumors. These characteristics make LeuΔPhe an attractive candidate for further development as a delivery platform for various biomedical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.